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Rabbit Anti-ING2 Polyclonal Antibody#abs133012

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Description

Catalog-specification	Delivery time	USD price
abs133012-50ug	1-2 Weeks	201.0
abs133012-100ug	1-2 Weeks	301.0

Overview
catalog	abs133012
Description	ING2 appears to play a role in the activation of p53/TP53 and the induction of p53/TP53-dependent apoptotic pathways by enhancing the acetylation of p53/TP53. It is also a component of a mSin3A-like corepressor complex, which is likely involved in the deacetylation of nucleosomal histones. The activity of ING2 seems to be influenced by its interaction with phosphoinositides (PtdInsPs).
Other names	The ING1 protein is known as a tumor suppressor, and it has a similar counterpart called ING1L. Another member of the ING family is ING2, which also functions as a tumor suppressor. These proteins play a role in inhibiting the growth of cells and are crucial in maintaining proper cell function. ING1Lp is a specific isoform of ING1L. The names "Inhibitor of growth 1 like" and "Inhibitor of growth family member" indicate that these proteins are involved in regulating cell growth processes. Additionally, the proteins p32 and p33ING2 are alternative names for ING2, highlighting its different isoforms. Overall, understanding the functions and interactions of these ING proteins is essential in the field of cancer research.
Source	Rabbit
Specificity	Total ING2 can be detected using the ING2 antibody, which specifically targets the endogenous levels of the protein.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Horse;Pig
Antigen	ING2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	33 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Tissue specificity	Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
Posttranslational modification	Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.
Celluar localization	Cytosol;Golgi apparatus;Nucleus;Plasma Membrane;
UniPort	Q9H160