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Rabbit Anti-HNF1A Polyclonal Antibody#abs136700

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Description

Catalog-specification	Delivery time	USD price
abs136700-100ug	1-2 Weeks	301.0
abs136700-50ug	1-2 Weeks	201.0

Overview
catalog	abs136700
Description	This particular gene produces a crucial protein that acts as a type of transcription factor. It plays a vital role in the expression of various liver-specific genes essential for liver function. The protein functions as a homodimer and essentially binds to a specific inverted palindrome sequence forming a complex structure. If there is a deficiency in this gene, it can lead to the onset of maturity onset diabetes of the young type 3 (MODY3) as well as the appearance of hepatic adenomas.
Other names	The Hepatic Nuclear Factor 1 Alpha, also known as HNF1A or TCF1, is a transcription factor that plays a crucial role in regulating gene expression in the liver. It is a liver-specific transcription factor LF-B1 that is responsible for activating genes involved in glucose and lipid metabolism. HNF1A is also associated with maturity onset diabetes of the young 3 (MODY3), a type of diabetes that is caused by defects in insulin secretion. Albumin proximal factor and interferon production regulator factor are other names for HNF1A, which highlights the multifaceted role this transcription factor plays. It is a key player in regulating liver-specific genes, with the ability to activate or suppress gene expression as needed. HNF1A is made up of two isoforms, HNF1Aα and HNF1Aβ, with HNF1Aα being the more common form found in the liver. Mutations in HNF1Aα have been linked to various liver disorders and diseases, including liver cancer, cirrhosis, and hepatitis B and C. Overall, HNF1A is an important transcription factor that plays a critical role in regulating liver gene expression and metabolism. Its complex nature and involvement in various liver disorders make it an essential target for future research and therapeutic interventions.
Source	Rabbit
Specificity	Total HNF1A levels can be detected by the HNF1A Antibody, which specifically targets endogenous HNF1A proteins.
Species Reactivity	Human;Mouse;Rat
Antigen	HNF1A
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthetic peptide of humanHNF1A.
MW	56kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, we successfully purified the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
Tissue specificity	Liver.
Celluar localization	Nucleus;
UniPort	P20823