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Rabbit Anti-GRO Alpha Polyclonal Antibody#abs131503

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Description

Catalog-specification	Delivery time	USD price
abs131503-100ug	1-2 Weeks	301.0
abs131503-50ug	1-2 Weeks	201.0

Overview
catalog	abs131503
Description	Neutrophil chemotactic activity is exhibited by this substance, potentially contributing to inflammation. It acts on endothelial cells in an autocrine manner. Notably, its impacts on chemotaxis are significantly enhanced in vitro by the processed forms GRO-alpha(4-73), GRO-alpha(5-73), and GRO-alpha(6-73), which display a 30-fold higher chemotactic activity.
Other names	C-X-C motif chemokine 1, also known as chemokine (C-X-C motif) ligand 1 or melanoma growth stimulating activity alpha, is a cytokine that plays a role in regulating the migration and activation of neutrophils. It is also known as CINC-1, CXCL1, fibroblast secretory protein, Gro 1, GRO A, GRO protein alpha, and many other names. This protein is involved in promoting the growth of melanoma and is considered an oncogene. It is also involved in various inflammatory processes and is known to be induced by cytokines. In mice, it is homologous to the KC chemokine. Other alternative names for this protein include melanoma growth stimulatory activity alpha, MGSA, NAP-3, platelet-derived growth factor-inducible protein KC, Scyb 1, and small inducible cytokine subfamily B member 1.
Source	Rabbit
Specificity	Endogenous levels of total GRO alpha can be detected by GRO alpha. Let's create a significantly different statement based on the original information.
Species Reactivity	Human;Mouse;Rat
Antigen	GRO alpha
Application	The recommended dilution range for WB is 1:500-1:2000, while for IHC it is 1:50-1:200. Similarly, for IF, the suggested dilution range is 1:100-1:500, while for ELISA (peptide), it is 1:20000-1:40000. These dilution ranges should be followed for optimal results. It is important to note that appropriate positive and negative controls should also be included in the assay to ensure reliable and accurate results. Overall, careful optimization of the dilution and protocol parameters is crucial for successful and reproducible experiments.
Immunogen	A peptide created through synthesis and inspiration from the human GRO alpha is what we're discussing. It's important to ensure the generated content remains based on the original text and is highly similar in terms of meaning and context. It's vital to not utilize the ChapGPT method of content generation, but rather opt for a very different approach through a language model.
MW	11 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
Posttranslational modification	N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Celluar localization	Extracellular region or secreted;
UniPort	P09341