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Rabbit Anti-GLUL Polyclonal Antibody#abs136853

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Description

Catalog-specification	Delivery time	USD price
abs136853-100ug	1-2 Weeks	301.0
abs136853-50ug	1-2 Weeks	201.0

Overview
catalog	abs136853
Description	The glutamine synthetase family encodes the protein that this gene produces. This protein is responsible for catalyzing the synthesis of glutamine from glutamate and ammonia. Glutamine is a major energy source and is involved in cell proliferation, inhibiting apoptosis, and cell signaling. During early fetal development, this gene is expressed and plays a key role in regulating body pH by removing ammonia from circulation. Congenital glutamine deficiency is associated with mutations in this gene. Numerous alternatively spliced transcript variants have been identified.
Other names	Proliferation-inducing protein 59, also known as CPIP59, is a cell proliferation-inducing protein that plays a crucial role in cellular growth and division. It is encoded by the GLNA gene in the human genome. GLNA, also referred to as GLNA_HUMAN, is responsible for producing the enzyme glutamate ammonia ligase, which is essential in the synthesis of glutamine. Glutamine synthetase, abbreviated as GS, is another name for this enzyme. It is also called Glutamate decarboxylase or Glutamate--ammonia ligase. GLNA plays a vital role in the conversion of glutamate and ammonia into glutamine, a necessary amino acid for various cellular processes. In addition to its involvement in glutamine synthesis, GLNA is associated with other cellular functions as well. It is also known as PIG 43 or PIG59, which stands for Proliferation Inducing Protein 43 or Proliferation Inducing Protein 59, respectively. These names highlight its role in promoting cell proliferation. Overall, GLNA, or glutamine synthetase, is an important protein involved in cell growth and division. Its activity as an ammonia ligase and its contribution to glutamine synthesis demonstrate its significance in maintaining cellular homeostasis.
Source	Rabbit
Specificity	The GLUL Antibody is designed to recognize total GLUL levels that are present naturally in the body. This means that the antibody is able to detect GLUL without any external intervention or manipulation.
Species Reactivity	Human;Mouse;Rat
Antigen	GLUL
Application	The recommended dilutions for Western Blot (WB) range from 1:500 to 1:2000. For Immunohistochemistry (IHC), the suggested dilutions are 1:50 to 1:200. When it comes to Immunofluorescence and Immunocytochemistry (IF/ICC), the suitable dilutions are between 1:100 and 1:500. Lastly, for ELISA with peptide samples, the dilutions should be from 1:20000 to 1:40000. It is crucial to follow these dilution guidelines to achieve accurate and reliable results in your experiments.
Immunogen	A synthesized peptide derived from human GLUL.
MW	42kDa
Properties
Concentration	1mg/ml
purification	A highly specific antiserum was obtained by means of peptide affinity chromatography. This technique involved utilizing the SulfoLink™ Coupling Resin to purify the antiserum to a high degree of purity.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
Tissue specificity	Expressed during early fetal stages.
Posttranslational modification	Ubiquitinated by ZNRF1.
Celluar localization	Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Mitochondrion;Nucleus;
UniPort	P15104