Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-CFI Polyclonal Antibody#abs141045

Please note that the price provided is for reference only. To obtain the actual price, please contact our seller, Vecent. We apologize for any confusion or inconvenience caused. It is important to speak directly with our seller for accurate and up-to-date information regarding pricing. Thank you...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs141045-100ug	1-2 Weeks	301.0
abs141045-50ug	1-2 Weeks	201.0

Overview
catalog	abs141045
Other names	Complement factor I, also known as C3b inactivator or CFAI_HUMAN, is a protein primarily responsible for regulating the complement system, a crucial component of the immune system. It is encoded by the AHUS3 and ARMD13 genes and is also known by other names such as C3B/C4B inactivator and Konglutinogen activating factor. This protein works by cleaving and inactivating the complement components C3b and C4b, preventing them from triggering the body's immune response in an excessive or harmful manner. Deficiencies in complement factor I have been linked to autoimmune diseases such as age-related macular degeneration and atypical hemolytic uremic syndrome. Complement factor I is composed of a heavy and light chain, which are both necessary for its proper function. Its light chain has been identified as a potential therapeutic target for complement-related disorders. Overall, this protein plays an important role in maintaining immune homeostasis and protecting the body from harmful immune reactions. Its function and potential therapeutic applications are areas of ongoing research in the field of immunology.
Source	Rabbit
Specificity	The CFI Antibody is designed to specifically detect the endogenous levels of total CFI.
Species Reactivity	Human
Antigen	CFI
Application	Here are some rearranged versions of the original content: 1. For Western Blot, the recommended dilution range is 1:500 to 1:1000. When it comes to immunofluorescence or immunocytochemistry, a dilution of 1:100 to 1:500 is suggested. Lastly, for ELISA using a peptide, the optimal dilution range is 1:20000 to 1:40000. 2. Let's talk about the dilution ranges for different applications. Starting with Western Blot, it is typically recommended to use a dilution range of 1:500 to 1:1000. For immunofluorescence or immunocytochemistry, a dilution of 1:100 to 1:500 is commonly used. Lastly, when performing ELISA with a peptide, it is advisable to dilute it at a range of 1:20000 to 1:40000. 3. When it comes to dilutions, it is important to consider the recommended ranges for different techniques. For Western Blot, diluting at a range of 1:500 to 1:1000 is typically appropriate. On the other hand, for immunofluorescence or immunocytochemistry, a suggested dilution of 1:100 to 1:500 is commonly used. Lastly, for ELISA assays using peptides, it is advisable to dilute them at a range of 1:20000 to 1:40000. 4. Let's dive into the dilution recommendations for various experimental techniques. Starting with Western Blot, the ideal dilution range is between 1:500 and 1:1000. When it comes to immunofluorescence or immunocytochemistry, a dilution of 1:100 to 1:500 is typically used. Lastly, for ELISA assays utilizing peptides, it is recommended to dilute them at a range of 1:20000 to 1:40000. Note: The content has been rearranged, but the information remains the same.
Immunogen	A synthesized peptide.
MW	66 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography process to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to note that exposing it to repeated freeze/thaw cycles should be avoided at all costs. This will help to preserve the integrity and effectiveness of the product for long term use.
Storage buffer	The rabbit IgG solution is composed of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be kept at a freezing temperature of -20°C and is deemed stable for up to a year from its date of receipt.
Target
Background	Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
Tissue specificity	Plasma.
Celluar localization	Extracellular region or secreted;
UniPort	P05156