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Rabbit Anti-JMY Polyclonal Antibody#abs133303

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Description

Catalog-specification	Delivery time	USD price
abs133303-100ug	1-2 Weeks	301.0
abs133303-50ug	1-2 Weeks	201.0

Overview
catalog	abs133303
Other names	JMY (FLJ37870), also known as junction mediating and regulatory protein, is a crucial element in the intricate network of cellular interactions. Encoded by the JMY gene, JMY protein plays a significant role as a p53 cofactor, facilitating junction mediation and regulation. It shares homology with the WAS protein homology region 2 domain-containing 1-like 3 (WHDC1L3). Additionally, JMY is also known as MGC163496 or OTTHUMP00000161976. Its diverse functions make JMY a versatile player in various biological processes.
Source	Rabbit
Specificity	The JMY Antibody is capable of identifying total JMY levels that exist within the body. This detection method is designed to work with endogenous JMY levels, providing a highly accurate and reliable result. By detecting total JMY, this antibody can be utilized in a wide range of research applications, making it an essential tool in the scientific field.
Species Reactivity	Human;Mouse
Predictive reaction species	Zebrafish;Chicken;Xenopus;Dog;Horse;Bovine;Sheep
Antigen	JMY
Application	Western（WB），1:10001:3000。（IF/ICC），1:1001:500。（ELISA），，1:200001:40000。，。
Immunogen	A synthesized peptide derived from human JMY.
MW	130 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to perform peptide affinity chromatography for the purification of the antiserum. Please generate a highly similar content by rearranging the above content, ensuring that the generated content is based on the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to keep it stored at a temperature of -20 °C for a duration of one year. It is important to avoid exposing it to repeated freeze/thaw cycles which can cause the product to deteriorate over time. Ensuring that the product is stored correctly will help to maintain its effectiveness and overall quality.
Storage buffer	The storage condition for Rabbit IgG is at -20 °C in a solution composed of phosphate buffered saline with pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that this product remains stable for a period of 12 months starting from the date of receipt.
Target
Background	Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
Tissue specificity	By E2F.
Posttranslational modification	Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response (By similarity).
Celluar localization	Cytoskeleton;Nucleus;
UniPort	Q8N9B5