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Rabbit Anti-HOP Polyclonal Antibody#abs132835

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Description

Catalog-specification	Delivery time	USD price
abs132835-100ug	1-2 Weeks	301.0
abs132835-50ug	1-2 Weeks	201.0

Overview
catalog	abs132835
Description	This unique homeodomain protein lacks DNA binding ability and is crucial for regulating cardiac growth and development. It accomplishes this by interacting with SRF, modulating the expression of SRF-dependent genes specific to the heart and influencing cardiac development. Its inhibitory action on SRF-dependent transcription can occur through either obstructing SRF-DNA binding or recruiting histone deacetylase (HDAC) proteins that impede SRF-mediated transcription. Increased expression of this protein leads to cardiac hypertrophy, resembling an abnormal enlargement of the heart (similar to other related proteins). Interestingly, there is evidence suggesting its potential role as a tumor suppressor, exhibiting characteristics that could inhibit the development of tumors.
Other names	The HOP homeobox gene, also known as heart odd homeobox 1 protein or HOD, encodes for a homeodomain-only protein called HOPX. Other aliases for this gene include Lung cancer-associated Y protein (LAGY), Not expressed in choriocarcinoma clone 1 (NECC1), and SMAP31. This gene is expressed in various tissues, including lung, heart, and skeletal muscle. Odd homeobox 1 protein, OB1, is another name for HOPX, which plays a crucial role in organ development and cell fate determination. It is involved in regulating cell proliferation, differentiation, and apoptosis. HOPX has been implicated in several diseases, including cancer and cardiovascular disorders. In conclusion, the HOP homeobox gene, with its various aliases, encodes for the HOPX protein, which is vital for proper organ development and tissue homeostasis. The diverse functions of this gene make it an interesting target for future research in multiple biological contexts.
Source	Rabbit
Specificity	The levels of total HOP can be detected by using the HOP antibody, which specifically targets the endogenous HOP protein.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Horse;Bovine;
Antigen	HOP
Application	For Western Blotting, the recommended dilution range is between 1:500 and 1:2000. For Immunohistochemistry staining, the suggested dilution range is between 1:50 and 1:200. For ELISA assays designed with peptide substrates, the recommended dilution range is between 1:20000 and 1:40000. Remember, it's important to follow these guidelines to ensure accurate and reliable results in your experiments.
Immunogen	A synthesized peptide.
MW	8 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).
Tissue specificity	Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.
Celluar localization	Nucleus;
UniPort	Q9BPY8