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Rabbit Anti-GATA2 Polyclonal Antibody#abs135637

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Description

Catalog-specification	Delivery time	USD price
abs135637-100ug	1-2 Weeks	301.0
abs135637-50ug	1-2 Weeks	201.0

Overview
catalog	abs135637
Description	GATA-2, a zinc finger transcription factor, is involved in various developmental processes and is widely expressed (1). Research conducted on mice lacking GATA-2 has revealed its crucial role in hematopoiesis (2). Additionally, GATA-2 acts as an inhibitor of white and brown adipocyte differentiation (3, 4) and has been found to suppress the proliferation of neuronal progenitor cells (5). These findings highlight the diverse functions of GATA-2 and its significance in multiple biological processes.
Other names	GATA2, also known as endothelial transcription factor GATA-2 or GATA binding protein 2, is a crucial factor involved in endothelial cell development and function. It plays a significant role in regulating gene expression related to endothelial cell biology. Other names for this transcription factor include FLJ45948, GATA2_HUMAN, IMD21, MGC2306, MONOMAC, NFE 1B, NFE1B, and OTTHUMP00000216240. GATA2 is a key player in the intricate transcriptional network governing the development and maintenance of endothelial cells. It contributes to the regulation of several target genes, which are essential for various endothelial functions such as angiogenesis, vasculogenesis, and vascular remodeling. The importance of GATA2 in endothelial cell biology is underscored by its association with various disorders and diseases. Mutations in GATA2 have been linked to several hematopoietic disorders, including myelodysplastic syndromes and acute myeloid leukemia. Additionally, dysregulation of GATA2 expression has been observed in cardiovascular diseases, such as atherosclerosis and pulmonary arterial hypertension. Understanding the intricate mechanisms by which GATA2 regulates gene expression in endothelial cells holds promise for developing novel therapeutic strategies to target endothelial dysfunction-related disorders. Further exploration of the complex signaling pathways and interaction partners of GATA2 is warranted to unravel its full potential as a therapeutic target.
Source	Rabbit
Specificity	Endogenous levels of total GATA2 can be detected using GATA2 Antibody. The GATA2 Antibody is designed to recognize and bind to all forms of endogenous GATA2 protein present in the sample. This allows for accurate and reliable detection of GATA2 levels in various biological samples. By utilizing this antibody, researchers can gain insight into the expression and regulation of GATA2 in different experimental settings.
Species Reactivity	Human;Mouse;Rat
Antigen	GATA2
Application	The recommended dilution range for this antibody is WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, and ELISA(peptide) 1:20000-1:40000. You can use this information to optimize your experimental conditions and ensure the best results for your research. It is important to follow the recommended dilution range as using an incorrect dilution can affect the sensitivity and specificity of the antibody. Overall, this antibody offers reliable and reproducible results for a variety of applications.
Immunogen	A synthesized peptide derived from human GATA2.
MW	49kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To achieve this, specialized techniques were implemented in which the resin was able to effectively couple the peptides in the sample and selectively isolate them from other compounds. The result was a highly purified antiserum product that was suitable for a range of biomedical applications.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Tissue specificity	Endothelial cells.
Celluar localization	Nucleus;
UniPort	P23769