Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-MAP3K12 Polyclonal Antibody#abs132729

Description

Catalog-specification	Delivery time	USD price
abs132729-100ug	1-2 Weeks	301.0
abs132729-50ug	1-2 Weeks	201.0

Please note that the price mentioned here is only for your reference. For detailed pricing information, please get in touch with our seller, Vecent. It is important to note that the generated content should be based on the original text information, but should be presented in a highly similar manner. We kindly request that you refrain from using the dialog generation method of ChapGPT and instead focus on generating text that is entirely different based on the language model.

Overview
catalog	abs132729
Description	The ability to activate the JNK/SAPK pathway suggests that it may be involved in signaling processes within the cell. It has been observed to phosphorylate various proteins, including beta-casein, histone 1, and myelin basic protein, in laboratory experiments. These findings highlight its potential role in modifying the function of these proteins and influencing cellular processes.
Other names	DLK, also known as dual leucine zipper bearing kinase or dual leucine zipper kinase, is a protein kinase that possesses a leucine-zipper motif. In humans, it is encoded by the gene M3K12_HUMAN. DLK is also referred to as Map3k12, MAPK-upstream kinase, MEKK12, mitogen-activated protein kinase kinase kinase 12, mixed lineage kinase, MUK, protein kinase MUK, ZPK, and ZPKP1.
Source	Rabbit
Specificity	The detection of endogenous levels of total MAP3K12 can be accomplished using a MAP3K12 antibody. This antibody specifically targets and identifies the total amount of MAP3K12 present within a sample. It provides reliable results and allows for the quantification of MAP3K12 protein levels. Hence, researchers can use this antibody to study the expression and regulation of MAP3K12 in various cellular processes and biological systems. Moreover, this antibody can also be used in diagnostic settings to evaluate the role of MAP3K12 in certain diseases or conditions. Overall, the MAP3K12 antibody serves as a valuable tool for researchers to explore the functional significance of MAP3K12 and its potential implications in different biological contexts.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	MAP3K12
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	95 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was applied to purify the antiserum utilizing SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	One year storage at -20 °C is recommended to maintain the quality of the product. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.
Tissue specificity	Highly expressed in brain and kidney.
Posttranslational modification	Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated (By similarity).
Celluar localization	Cytosol;Plasma Membrane;
UniPort	Q12852