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Rabbit Anti-ACVR1C Polyclonal Antibody#abs135638

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Description

Catalog-specification	Delivery time	USD price
abs135638-100ug	1-2 Weeks	301.0
abs135638-50ug	1-2 Weeks	201.0

Overview
catalog	abs135638
Description	ACTR-IC, also known as ALK-7, is a type I serine/threonine kinase receptor called Activin receptor type 1C. It possesses an extracellular binding domain, an intracellular serine/threonine kinase domain preceded by a GS box, and a transmembrane domain. Its expression is found throughout the digestive and central nervous system, with localization to the cell surface. Through alternative splicing, four ACTR-IC transcripts are produced. Among these, transcript 1 represents the functional full-length receptor, while transcript 2 lacks a complete receptor binding domain. Transcripts 3 and 4 code for soluble proteins that do not possess a transmembrane domain. ACTR-IC acts as a receptor for Activin AB, Activin B, and Nodal. In pancreatic cells, it forms a complex with Activin receptor type IIB (ACTR-IIB). The kinase domain of ACTR-IC is capable of activating both Smad2 and Smad3 signaling pathways. Interestingly, overexpression of ACTR-IC has been shown to induce apoptosis and inhibit cell proliferation in certain cell lines. To summarize, ACTR-IC, also referred to as ALK-7, is a type I serine/threonine kinase receptor. It is expressed in various tissues and acts as a receptor for Activin AB, Activin B, and Nodal. ACTR-IC plays a role in pancreatic cells by forming a complex with ACTR-IIB and activating Smad2 and Smad3 signaling. Furthermore, its overexpression has been observed to induce apoptosis and inhibit cell proliferation in specific cell lines.
Other names	IC Activin A receptor; Activin-like kinase 7 receptor; precursor of type 1C Activin receptor; Activin receptor IC; Type-1C Activin receptor; Activin receptor-like kinase 7; ACTR IC; ACTR-IC; ACTRIC; ACV1C_HUMAN; Acvr1c; ACVRLK7; ALK 7; ALK-7; ALK7.
Source	Rabbit
Specificity	The endogenous levels of total ACVR1C can be detected by the ACVR1C Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Horse;Bovine
Antigen	ACVR1C
Application	The recommended dilutions for Western blotting range from 1:500 to 1:2000, while for immunohistochemistry a dilution of 1:50 to 1:200 is suggested. When using ELISA with a peptide, the recommended dilutions are between 1:20000 to 1:40000. It's important to follow these dilution guidelines in order to obtain accurate and reliable results in your experiments. By adjusting the concentration of your primary antibody, you can optimize your protocols and enhance the specificity and sensitivity of your detection. So be sure to take note of the recommended dilutions and adjust accordingly for your experimental needs.
Immunogen	A synthesized peptide derived from human ACVR1C.
MW	55kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Tissue specificity	Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
Celluar localization	Plasma Membrane;
UniPort	Q8NER5