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Rabbit Anti-CCNA2 Polyclonal Antibody#abs132680

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Description

Catalog-specification	Delivery time	USD price
abs132680-50ug	1-2 Weeks	201.0
abs132680-100ug	1-2 Weeks	301.0

Overview
catalog	abs132680
Description	To ensure proper regulation of the cell cycle, it is essential to control the transitions that occur between the G1/S (start) and G2/M (mitosis) phases. These critical checkpoints are responsible for ensuring that the cell progresses through the various phases of the cell cycle in a timely and coordinated manner. Without proper control and regulation at these transition points, the cell can become unstable and may even lead to the formation of tumors or other abnormalities. As such, understanding the mechanisms that govern these crucial transitions is of utmost importance in the study of cellular biology.
Other names	Here are a few possible rephrased versions: 1. Cyclin A2, also known as CCNA2 or Cyclin-A, is a protein that plays an important role in cell cycle regulation. It is encoded by the CCNA2 gene in humans. 2. CCNA2_HUMAN, or Cyclin A2, is a cyclin protein that is involved in the regulation of cell division. It is a key component of the cyclin-dependent kinase (CDK) complex, which controls the progression of cells through the various phases of the cell cycle. 3. CCN1 (Cyclin D1) and CCNA2 (Cyclin A2) are two important cyclin proteins that are involved in the control of cell cycle progression. While CCN1 is primarily expressed in the G1 phase of the cell cycle, CCNA2 is involved in the transition from G1 to S phase. Both proteins are critical for maintaining proper cell cycle regulation and preventing the development of cancer. 4. The CCNA2 gene encodes for Cyclin A2, which is a member of the cyclin protein family. Cyclin A2 is involved in the regulation of DNA synthesis and cell division, and it is essential for the proper progression of the cell cycle. Aberrant expression of Cyclin A2 has been linked to the development of various types of cancer.
Source	Rabbit
Specificity	The CCNA2 antibody has the ability to identify the levels of total CCNA2 that occur naturally within the body. Using this antibody allows for the detection of CCNA2 without any external interference.
Species Reactivity	Human;Mouse;Rat
Antigen	CCNA2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	50 kDa
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification. An effective method for isolating targeted molecules, peptide affinity chromatography helped in purifying the antiserum, resulting in a high-quality product.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles during storage.
Storage buffer	150NaCl、pH7.4IgG。，0.02%50%。，。
Target
Background	Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Tissue specificity	Accumulates steadily during G2 and is abruptly destroyed at mitosis. Not detected during the G1 phase of the cell cycle. It accumulates during the DNA synthesis/S phase and disappears as cells progress into mitosis, between prophase and metaphase (at protein level).
Posttranslational modification	Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
Celluar localization	Cytosol;Nucleus;
UniPort	P20248