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Rabbit Anti-PSMG2 Polyclonal Antibody#abs135640

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Description

Catalog-specification	Delivery time	USD price
abs135640-100ug	1-2 Weeks	301.0
abs135640-50ug	1-2 Weeks	201.0

Overview
catalog	abs135640
Description	PSMG1 plays a crucial role in chaperoning the assembly of the 20S proteasome. The protein forms a heterodimer with PSMG2, which binds to proteasome subunits PSMA5 and PSMA7. This binding enhances the assembly of alpha subunits into a heteroheptameric alpha ring, while also preventing alpha ring dimerization. Overall, PSMG1-PSMG2 heterodimer facilitates the assembly of the proteasome, a process essential for the proper functioning of the proteolytic machinery.
Other names	CD40 ligand activated specific transcript 3, also known as CLAST3 or HCCA3, is a protein that is implicated in hepatocellular carcinoma susceptibility. It is also referred to as hepatocellular carcinoma-susceptibility protein 3 or HSPC260. In addition, it is known by alternative names such as HsT1707, likely ortholog of mouse CD40 ligand activated specific transcript 3, MDS003, PAC-2, PAC2, proteasome (prosome, macropain) assembly chaperone 2, or simply PSMG2. This protein, encoded by the TNFSF5IP1 gene, is involved in the assembly of proteasomes, which are responsible for protein degradation. It plays a crucial role as a chaperone in the formation and stability of these proteasomes. Understanding the functions and mechanisms of CD40 ligand activated specific transcript 3 can significantly contribute to the comprehension and potential treatment of hepatocellular carcinoma, a type of liver cancer. Further research and exploration of this protein may provide insights into its precise role in disease development and management.
Source	Rabbit
Specificity	The detection of total PSMG2 at its endogenous expression levels can be achieved by using the PSMG2 Antibody. To clarify, the antibody specifically recognizes and binds to the complete PSMG2 protein present within the cell. This means that the antibody can help researchers accurately identify and measure the total amount of PSMG2 in a sample. By detecting the endogenous levels of PSMG2, scientists can gain insights into its biological functions and potentially uncover its role in various cellular processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig
Antigen	PSMG2
Application	For Western blotting, the recommended dilution range is 1:500 to 1:2000. When it comes to immunohistochemistry, the suggested dilution is 1:50 to 1:200. For ELISA using peptides, it is advised to dilute at 1:20000 to 1:40000. Feel free to arrange the information as needed to maintain its accuracy.
Immunogen	A synthesized peptide derived from human PSMG2.
MW	29kDa
Properties
Concentration	1mg/ml
purification	To obtain a purified antiserum, the SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Tissue specificity	Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue.
Posttranslational modification	Degraded by the proteasome upon completion of 20S proteasome maturation.
Celluar localization	Cytosol;Nucleus;
UniPort	Q969U7