Rabbit Anti-FYCO1 Polyclonal Antibody #abs130316

abs130316-50ug

1-2 Weeks

201

abs130316-100ug

1-2 Weeks

301

Other names

Protein FYCO1, also known as FYVE and coiled-coil domain containing 1 or Zinc finger FYVE domain-containing protein 7, is encoded by the FYCO1 gene. It is a multifunctional protein involved in various cellular processes.
FYCO1 contains a FYVE domain and a coiled-coil domain. The FYVE domain enables FYCO1 to bind to phosphatidylinositol-3-phosphate (PI3P), which is found on the surface of specific cellular membranes. This interaction allows FYCO1 to localize to these membranes and participate in membrane trafficking events.
The coiled-coil domain in FYCO1 is responsible for protein-protein interactions. It allows FYCO1 to interact with other proteins and form complexes involved in vesicle transport, autophagy, and endosomal sorting.
FYCO1 has been implicated in autophagy, a cellular process that involves the degradation of damaged organelles and proteins. It plays a role in the early steps of autophagosome formation, where it recruits autophagy-related proteins to the site of autophagosome initiation.
In addition to its role in autophagy, FYCO1 has also been implicated in other cellular processes. It is involved in vesicle trafficking, where it participates in the transport of vesicles between different cellular compartments. FYCO1 has been shown to interact with proteins involved in endocytosis and exocytosis, suggesting its involvement in these processes as well.
Furthermore, FYCO1 has been linked to diseases such as cancer. Dysregulation of FYCO1 expression has been observed in various cancer types, and its overexpression or downregulation has been associated with tumor growth, metastasis, and chemotherapy resistance.
In summary, FYCO1 is a versatile protein involved in multiple cellular processes, including autophagy, vesicle trafficking, and endosomal sorting. Its diverse functions and interactions make it an interesting target for further investigation in both normal cellular physiology and disease contexts.

Source

Rabbit

Specificity

The detection of total FYCO1 at its endogenous levels can be achieved using FYCO1 antibody. Let me know if you need any further assistance!

Species Reactivity

Human;Rat

Application

WB: 1:500~1:3000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human FYCO1.

Properties

Concentration

1mg/ml

Purification

Utilizing SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To ensure a highly similar content, the information from the original text was rephrased while maintaining its context.

Clonality

Polyclonal Antibody

Stability & Storage

To ensure long-term storage stability, it is recommended to keep the material at a freezing temperature of -20 °C for a year. Care should be taken to prevent repeated cycles of freezing and thawing, as this can negatively impact the integrity of the material. It is advisable to follow these guidelines to maintain the quality of the material and avoid any degradation during storage.

Storage buffer

This product is Rabbit IgG dissolved in a solution of phosphate buffered saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. To maintain its stability, it should be stored at a temperature of -20 °C. It has a shelf life of 12 months starting from the date of receipt.

Target

Background

The capability to facilitate microtubule plus end-directed vesicle transport is possessed by May. By rearranging the above information, a highly similar sentence can be generated.

Tissue specificity

Expressed in heart and skeletal muscle.

Celluar localization

Endosome;Golgi apparatus;Lysosome;

UniPort

Q9BQS8