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Rabbit Anti-FUS Polyclonal Antibody#abs137868

Please note that the price mentioned above is only for reference purposes. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis FUS using K562 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs137868-100ug	1-2 Weeks	301.0
abs137868-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for reference purposes. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs137868
Other names	Fused in Sarcoma (FUS) is a 75 kDa DNA pairing protein that is associated with various conditions, including Amyotrophic Lateral Sclerosis 6 (ALS6) and liposarcoma. It plays a crucial role in DNA pairing and is also known as Fusion protein involved in t(12;16) in malignant liposarcoma. FUS is an RNA binding protein that belongs to the heterogeneous nuclear ribonucleoprotein family, specifically the hnRNP P2 subgroup. Another name for FUS is Translocated in Liposarcoma (TLS), which signifies its involvement in fusion genes associated with liposarcoma. It is also referred to as POMp75, reflecting its molecular weight and function.
Source	Rabbit
Specificity	The FUS Antibody is capable of recognizing the total levels of endogenous FUS in an organism. The antibody is specifically designed to target the native FUS protein and can be used in various experimental assays. The detection of FUS using this antibody can aid in elucidating the role of FUS in various biological processes. Researchers can rely on this antibody to study FUS in different organisms and tissues with high specificity. Overall, the FUS Antibody is an essential tool for researchers investigating the role of FUS in different contexts.
Species Reactivity	Human;Mouse
Predictive reaction species	Xenopus;Zebrafish;Chicken;Pig;Dog;Bovine;
Antigen	FUS
Application	The recommended dilution for Western blotting is between 1:1000-3000, while for immunohistochemistry it is 1:200. For ELISA using a peptide, the suggested dilution ranges from 1:20000-1:40000. It is important to adhere to the given dilution range for optimal results in these assays.
Immunogen	A synthesized peptide derived from human FUS.
MW	53 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar version could be: The peptide affinity chromatography of the antiserum was achieved through purification with SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
Tissue specificity	Ubiquitous.
Posttranslational modification	Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.
Celluar localization	Nucleus;
UniPort	P35637