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Rabbit Anti-MUC16 Polyclonal Antibody#abs137466

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Description

Catalog-specification	Delivery time	USD price
abs137466-100ug	1-2 Weeks	301.0
abs137466-50ug	1-2 Weeks	201.0

Overview
catalog	abs137466
Other names	CA 125 is also known as cancer antigen 125 or CA125. It is an ovarian cancer antigen that is used as a tumor marker in clinical settings. The gene encoding CA125 is called FLJ14303, and its protein product is known as MUC16 or mucin 16. MUC16 is a cell surface-associated mucin that is specifically associated with ovarian cancer. It plays a crucial role in the progression and diagnosis of ovarian cancer. The presence of elevated levels of CA125 in the blood is indicative of ovarian cancer. Therefore, CA125 is considered an important ovarian cancer-related tumor marker. Its identification and measurement provide valuable information for the diagnosis and management of ovarian carcinoma.
Source	Rabbit
Specificity	The MUC16 Antibody is capable of identifying the total amount of MUC16 present in the body. This detection is based on the detection of endogenous levels of MUC16 that are naturally occurring within the body. By detecting these levels, the antibody can provide insight into the amount and distribution of MUC16 within various tissues and organs. This information is critical for understanding the role of MUC16 in physiological and pathological processes.
Species Reactivity	Human
Antigen	MUC16
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MUC16.
MW	2353 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized to conduct peptide affinity chromatography in order to purify the antiserum. This process was successful in producing a highly purified and potent antiserum product.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of your product, keep it stored at a temperature of -20 °C for up to one year. It's important to avoid exposing the product to freeze/thaw cycles repeatedly, as this can damage its integrity over time. Ensure that you follow these guidelines carefully to ensure that your product maintains its quality and potency for as long as possible.
Storage buffer	This rabbit IgG solution is formulated in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, and a trace amount of sodium azide to prevent microbial growth. Additionally, this solution consists of 50% glycerol to promote stability. This solution should be stored at -20°C and is expected to remain stable for up to one year upon receipt.
Target
Background	Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Tissue specificity	Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
Posttranslational modification	Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Celluar localization	Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	Q8WXI7