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Rabbit Anti-FGR Polyclonal Antibody#abs133383

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Description

Catalog-specification	Delivery time	USD price
abs133383-50ug	1-2 Weeks	201.0
abs133383-100ug	1-2 Weeks	301.0

Overview
catalog	abs133383
Other names	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as c-fgr or proto-oncogene c-fgr, is a protein involved in cell signaling pathways and cancer development. Its human counterpart, FGR_HUMAN, is a tyrosine protein kinase encoded by the FLJ43153 gene. The p55 and p58 forms of the Fgr protein are different isoforms resulting from alternative splicing. The p55 FGR or p55c-fgr and p58 Fgr or p58c-fgr variants contribute to the diverse functions of this proto-oncogene. SRC2, also referred to as c-src2, is another proto-oncogene tyrosine protein kinase related to Fgr. Both FGR and SRC2 play critical roles in cell growth, differentiation, and transformation processes. MGC75096 is a gene associated with FGR that has been studied for its implications in cancer research. By rearranging the above information, the generated content will have a different structure and flow while still being based on the original text details.
Source	Rabbit
Specificity	The detection capability of the FGR Antibody is focused on measuring the levels of total FGR present within an organism. It effectively targets and identifies the endogenous amounts of FGR protein. By utilizing this antibody, researchers can gain valuable insights into the overall levels of FGR within a biological system.
Species Reactivity	Human;Mouse;Rat
Antigen	FGR
Application	For Western Blot analysis, a dilution of 1:500 to 1:1000 is recommended. Immunofluorescence or immunocytochemistry analysis should be performed at a dilution of 1:100 to 1:500. If you are performing an ELISA assay using a peptide, a dilution of 1:20000 to 1:40000 is recommended for optimal results. Please ensure that you follow these recommended dilutions for accurate and reliable results in your experiments.
Immunogen	A synthesized peptide.
MW	55 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To ensure high-quality results, this process was carefully executed to obtain a pure form of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is necessary to store it at a temperature of -20 °C for a period of one year. It is important to avoid any instances of repeated freezing and thawing cycles to ensure the product remains stable. By adhering to the recommended storage conditions, the product can maintain its effectiveness and efficiency for an extended period of time.
Storage buffer	This is a formulation for Rabbit IgG that comes packaged in phosphate buffered saline with a pH of 7.4, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal stability, it should be stored at -20°C, and it remains stable for up to 12 months from the date it was received.
Target
Background	Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Tissue specificity	Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
Posttranslational modification	Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation.Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Mitochondrion;Plasma Membrane;
UniPort	P09769