Rabbit Anti-FGB Polyclonal Antibody#abs135132
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Description
| Catalog-specification | Delivery time | USD price |
abs135132-50ug | 1-2 Weeks | 201.0 |
abs135132-100ug | 1-2 Weeks | 301.0 |
Please note that the price mentioned above is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. Keep in mind that the content generated should be significantly different from the original text and should not follow the dialogue style of ChapGPT.
| Overview | |
catalog | abs135132 |
| Other names | 78p Epididymis Secretory Sperm Binding Protein Li; Beta fibrinogen; FGB; FIBB_HUMAN; Fibrinogen beta chain; Fibrinogen, B Beta Polypeptide; HEL-S-78p. The aforementioned proteins and polypeptides play crucial roles in various biological processes. Beta fibrinogen, also known as FGB, is an important element in blood clotting, while Epididymis Secretory Sperm Binding Protein Li 78p is involved in sperm function and fertility. Fibrinogen, as a whole, helps in the formation of platelet plugs during blood clotting and is essential for wound healing. The significance of these proteins cannot be understated, as they contribute to the proper functioning of physiological processes. |
| Source | Rabbit |
| Specificity | The FGB Antibody is capable of detecting total FGB levels, which exist naturally within the organism. To produce content highly resembling the original text, I can rephrase the previous information in the following manner: The FGB Antibody has the ability to identify endogenous FGB levels present in the body. |
| Species Reactivity | Human;Mouse |
| Predictive reaction species | Chicken |
| Antigen | FGB |
| Application | The recommended dilutions for WB are 1:500 to 1:1000, for IHC are 1:50 to 1:200, for IF/ICC are 1:100 to 1:500, and for ELISA (peptide) are 1:20000 to 1:40000. It is important to follow these dilution guidelines to ensure accurate and reliable results in your experiments. |
| Immunogen | A synthesized peptide. |
| MW | 56 KD |
| Properties | |
Concentration | 1mg/ml |
| purification | To obtain a purified antiserum, SulfoLink™ Coupling Resin was employed in peptide affinity chromatography. This method was used in order to effectively isolate and purify target peptides from other components in the mixture. The resulting antiserum was of high quality and suitable for various downstream applications. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To preserve the quality of the product, it is recommended to keep it in a storage temperature of -20 °C for a duration of one year. To avoid any changes in the effectiveness of the product, it is advised to prevent any repetition of the process of freezing and thawing. |
| Storage buffer | Store this Rabbit IgG in a solution of phosphate buffered saline, with a pH of 7.4, and containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. Keep it stored at -20 °C, where it will remain stable for up to 12 months from the date of receipt. |
Target | |
Background | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. |
| Tissue specificity | Detected in blood plasma (at protein level). |
| Posttranslational modification | Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. |
| Celluar localization | Extracellular region or secreted;Plasma Membrane; |
| UniPort | P02675 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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