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Rabbit Anti-CREB3L3 Polyclonal Antibody#abs132961

Please note that the mentioned price is for reference purposes only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs132961-100ug	1-2 Weeks	301.0
abs132961-50ug	1-2 Weeks	201.0

Please note that the mentioned price is for reference purposes only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.

Overview
catalog	abs132961
Other names	CREB H, also known as cAMP responsive element binding protein 3 like 3 or CREB/ATF family transcription factor, is a transcription factor that plays a role in various cellular processes. It is involved in the regulation of gene expression through binding to specific DNA sequences known as cAMP responsive elements. CREB H is also implicated in the unfolded protein response, a cellular stress response pathway that is activated upon the accumulation of misfolded proteins in the endoplasmic reticulum. Research has suggested that dysregulation of CREB H may be involved in the pathogenesis of various diseases, including metabolic disorders and cancer. Although much remains to be elucidated about the exact functioning of CREB H, it is clear that this transcription factor plays an important role in maintaining cellular homeostasis and responding to stress.
Source	Rabbit
Specificity	The total CREB3L3 levels can be detected using the CREB3L3 antibody, which specifically recognizes the endogenous amounts of the protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Chicken;Sheep;Dog;
Antigen	CREB3L3
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	49 kDa
Properties
Concentration	1mg/ml
purification	The purification of the antiserum involved the utilization of SulfoLink™ Coupling Resin in a peptide affinity chromatography process.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure maximum longevity of the product, we recommend storing it at a temperature of -20 °C for up to one year. Please keep in mind that repeated cycles of freezing and thawing should be avoided to prevent any potential damage.
Storage buffer	The formulation of the rabbit IgG solution includes phosphate buffered saline with pH 7.4, 150mM NaCl, and 0.02% sodium azide. Additionally, the solution contains 50% glycerol to assist with preservation.
Target
Background	Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.
Tissue specificity	Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.
Posttranslational modification	Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans.
Celluar localization	Cytosol;Endoplasmic reticulum;Golgi apparatus;Nucleus;
UniPort	Q68CJ9