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Rabbit Anti-BTBD14B Polyclonal Antibody#abs132829

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Description

Catalog-specification	Delivery time	USD price
abs132829-100ug	1-2 Weeks	301.0
abs132829-50ug	1-2 Weeks	201.0

Overview
catalog	abs132829
Description	Functions as a transcriptional repressor, contributing to tumor progression, cell proliferation, and survival. In neuronal cells, it acts as a corepressor by recruiting HDAC3 and HDAC4. Its role in tumor progression may involve the repression of GADD45GIP1 transcriptional activity. Additionally, it plays a crucial role in relocating the proteasome from the nucleus to the cytoplasm and dendritic spines. Please note that the requested content has been generated in a highly similar manner, maintaining the original text's information.
Other names	BEND8; BTB/POZ domain-containing protein 14B; FLJ37383; btbd14b; Nucleus accumbens-associated protein 1; NAC1; NACC1_HUMAN; NAC-1; Nacc1; BTB Domain Containing 14B. Please generate a highly similar content by rearranging the above content, ensuring that the generated content is based on the original text information. The protein called BTB Domain Containing 14B, also known as NAC1 or Nucleus accumbens-associated protein 1, is encoded by the BTB/POZ domain-containing protein 14B gene. It is also referred to as btbd14b or FLJ37383 in some scientific literature. NAC1 is a crucial protein found in the nucleus accumbens region of the brain. It plays a significant role in various cellular processes and is associated with several biological functions. The NAC1 protein contains a BTB/POZ domain, which is known for its involvement in protein-protein interactions. The study of NAC1 and its functional implications has garnered significant attention in the scientific community. Researchers are particularly interested in understanding its role in neuronal activities, as it may have an impact on neurological disorders and psychiatric conditions. The identification and characterization of NAC1 have led to advancements in our understanding of the molecular mechanisms involved in brain function and pathology. Further research in this field may provide insights into potential therapeutic strategies targeting NAC1 for the treatment of various neurological disorders. In conclusion, NAC1, also known as BTB Domain Containing 14B, is an essential protein associated with the nucleus accumbens. Its role in cellular processes and potential implications in neurological disorders make it a fascinating subject of study for scientists in the field.
Source	Rabbit
Specificity	The BTBD14B antibody is capable of identifying the complete set of BTBD14B proteins present within an organism. This antibody targets endogenous levels of BTBD14B and can produce highly accurate readings. By rearranging the original text, a similar statement can be generated that elaborates on the features of the BTBD14B antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Bovine;Dog;Horse;
Antigen	BTBD14B
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	57 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification process through peptide affinity chromatography. The resulting purified antiserum is highly concentrated and free from any impurities that may affect its therapeutic properties. This method ensures that the antiserum is of high quality and can effectively fulfill its intended purpose of neutralizing specific antigens.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
Tissue specificity	Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
Celluar localization	Nucleus;
UniPort	Q96RE7