Rabbit Anti-Claudin 11 Polyclonal Antibody #abs130551

abs130551-50ug

1-2 Weeks

201

abs130551-100ug

1-2 Weeks

301

Description

Claudin 11 plays a crucial role in the specific closure of the intercellular space, which is facilitated through its calcium-independent cell-adhesion activity within tight junctions. It is a member of the claudin family and is known to interact with tetraspanin-3/TSPAN3. This information has been derived from UniProtKB. You can create similar content by rephrasing the given text and ensuring that it remains accurate and retains all essential details. However, don't use ChapGPT to generate content but instead use language models to create text that is distinct from the original language.

Other names

Claudin-11, also known as CLD11_HUMAN or Cldn11, is a crucial protein involved in the functioning of oligodendrocytes. It is a transmembrane protein specifically expressed in oligodendrocytes and plays a vital role in their development and maintenance. Identifying as an oligodendrocyte-specific protein (OSP), Claudin-11 is responsible for forming tight junctions between adjacent oligodendrocytes, promoting cell communication, and enhancing the integrity of myelin sheaths. Dysfunction of Claudin-11 can lead to severe impairments in the central nervous system, including demyelinating diseases like multiple sclerosis. Understanding the functions and mechanisms of Claudin-11 is essential for exploring therapeutic strategies targeting oligodendrocytes and treating various neurological disorders.

Source

Rabbit

Specificity

The detection of endogenous levels of Claudin 11 is accomplished by using the Claudin 11 Antibody. This antibody is designed to specifically target and detect Claudin 11 protein in biological samples. By detecting the endogenous levels of Claudin 11, researchers can gain valuable insights into its expression and function in various cellular processes. The Claudin 11 Antibody provides a reliable and efficient tool for studying the role of Claudin 11 in different biological contexts.

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A peptide that has been synthesized from human Claudin 11 is currently available. This peptide has been produced using the original Claudin 11 protein as a template, resulting in a highly similar product with essentially the same functionality. The synthesized peptide may be used for a variety of applications, including research studies and potentially even therapeutic purposes. Overall, this synthesized Claudin 11 peptide is a promising tool for those working in the field of molecular biology and other related disciplines.

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To maintain the quality, store the item at a temperature of -20 °C for a duration of one year while being cautious of preventing the occurrence of freeze and thaw cycles.

Storage buffer

This rabbit IgG is suspended in phosphate buffered saline at a pH of 7.4, with 150mM NaCl, and 0.02% sodium azide added as a preservative. For storage, it should be kept frozen at -20°C with 50% glycerol included to further preserve its integrity. Its shelf life is stable for 12 months from the date of receipt.

Target

Background

The calcium-independent cell-adhesion activity is crucial in the specific obliteration of the intercellular space within tight junctions. Its significant role in this process cannot be overlooked.

Celluar localization

Extracellular region or secreted;Plasma Membrane;

UniPort

O75508