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Rabbit Anti-CHD8 Polyclonal Antibody#abs138903

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Description

Catalog-specification	Delivery time	USD price
abs138903-100ug	1-2 Weeks	301.0
abs138903-50ug	1-2 Weeks	201.0

Overview
catalog	abs138903
Other names	CHD8 is an ATP-dependent helicase that plays a crucial role in various cellular processes. Also known as ATP-dependent helicase CHD8 or Chromodomain-helicase-DNA-binding protein 8, this protein is involved in axis duplication inhibition and binds to beta catenin. It is encoded by the CHD8 gene and is sometimes referred to as Chromodomain helicase DNA binding protein 8 or Duplin. CHD8 contains the helicase with SNF2 domain 1, also known as HELSNF1. Another name for CHD8 is KIAA1564. It should be noted that this information has been rearranged to create a new content based on the original text.
Source	Rabbit
Specificity	The total CHD8 levels can be identified using the CHD8 Antibody, which is capable of detecting endogenous levels of CHD8.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Dog;Horse;
Antigen	CHD8
Application	IHC 1:200, WB 1:1000-3000, and ELISA (peptide) 1:20000-1:40000 are the recommended dilutions for different laboratory techniques.
Immunogen	A synthesized peptide derived from human CHD8.
MW	290kDa
Properties
Concentration	1mg/ml
purification	Through the utilization of SulfoLink™ Coupling Resin, the antiserum underwent purification utilizing peptide affinity chromatography techniques.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition is to keep the product frozen at -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	The provided information states that Rabbit IgG is stored in phosphate buffered saline at a pH of 7.4. The solution contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C. The stability of the solution is guaranteed for a period of 12 months from the date of receipt.
Target
Background	DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
Posttranslational modification	Sumoylated.
Celluar localization	Nucleus;
UniPort	Q9HCK8