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Rabbit Anti-CD79A Polyclonal Antibody#abs135105

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Description

Catalog-specification	Delivery time	USD price
abs135105-100ug	1-2 Weeks	301.0
abs135105-50ug	1-2 Weeks	201.0

Overview
catalog	abs135105
Other names	The alpha chain of the B lymphocyte-specific MB1 protein is known as B-cell antigen receptor complex-associated protein. It is also referred to as CD 79a or CD79a antigen. This protein, also known as CD79A, plays a crucial role in B-cell development and activation. It is a molecule associated with immunoglobulin and is commonly referred to as Ig alpha or IGA. Another term used for this protein is IgM-alpha, which indicates its association with IgM. Moreover, it is also referred to as Ly54, MB-1 membrane glycoprotein, and membrane-bound immunoglobulin-associated protein. Its primary function is to be surface IgM-associated protein.
Source	Rabbit
Specificity	The CD79A Antibody can identify the overall amount of CD79A present within the system. This recognition occurs naturally at endogenous levels, allowing for a precise level of detection. For further clarification, it should be noted that this antibody only targets CD79A and no other proteins or compounds.
Species Reactivity	Human
Antigen	CD79A
Application	For western blotting, the recommended dilution range is 1:500 to 1:1000. When using this technique for immunofluorescence or immunocytochemistry, the optimal dilution is between 1:100 and 1:500. If you're conducting an ELISA with peptide, it's best to use a dilution range of 1:20000 to 1:40000. It's important to follow these guidelines to ensure the accuracy and reliability of your results.
Immunogen	A synthesized peptide.
MW	25 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography purification in order to achieve high purity levels.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage, it is recommended to keep the product at a temperature of -20 °C for up to one year. It is advised to avoid exposing the product to repeated cycles of freezing and thawing. Proper storage and handling of the product can help maintain its stability and efficacy over time.
Storage buffer	This solution contains Rabbit IgG dissolved in phosphate buffered saline at pH 7.4, with the addition of 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal storage, it is recommended to store this solution at a temperature of -20°C. This particular solution has a shelf life of 12 months from the date of receipt.
Target
Background	Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Tissue specificity	B-cells.
Posttranslational modification	Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).
Celluar localization	Endosome;Plasma Membrane;
UniPort	P11912