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Rabbit Anti-FCGR2C Polyclonal Antibody#abs135104

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Description

Catalog-specification	Delivery time	USD price
abs135104-100ug	1-2 Weeks	301.0
abs135104-50ug	1-2 Weeks	201.0

Overview
catalog	abs135104
Other names	The Fc fragment of IgG low affinity II receptor, also known as CD32, encompasses various isoforms such as CD32A, CD32B, CD32C, and CDw32. These isoforms react with different antigens and are expressed on different cells. Furthermore, Fc gamma receptor II includes three subunits - Fc gamma RIIa, Fc gamma RIIb, and Fc gamma RIIc - and can bind with low affinity to the IgG Fc region. Other synonyms of Fc gamma receptor II are IgG Fc receptor II, IGFR2, and Ly-17. It is noteworthy that this protein is important for regulating immune responses, and its dysregulation can lead to autoimmune diseases. Additionally, Fc gamma receptor II can act as a target for immunotherapeutic approaches aimed at treating inflammatory disorders.
Source	Rabbit
Specificity	The FCGR2C Antibody is capable of recognizing total FCGR2C levels present in the body. This implies that it is effective in detecting endogenous FCGR2C. To create unique content, the information provided in the original text has been rearranged accordingly.
Species Reactivity	Human
Antigen	FCGR2C
Application	The dilution recommended for Western Blot is 1:500 to 1:1000, whereas for IF/ICC, the ideal range is from 1:100 to 1:500. When conducting ELISA with peptide as the antigen, the suggested dilution for antibodies is 1:20000 to 1:40000. It is important to note that these recommendations are based on the original text information and should be followed accordingly.
Immunogen	A synthesized peptide.
MW	35 KD
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
Tissue specificity	Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.
Posttranslational modification	Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.
Celluar localization	Plasma Membrane;
UniPort	P31995