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Rabbit Anti-CCRN4L Polyclonal Antibody#abs138348

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Description

Catalog-specification	Delivery time	USD price
abs138348-100ug	1-2 Weeks	301.0
abs138348-50ug	1-2 Weeks	201.0

Overview
catalog	abs138348
Other names	The CCR4 protein homolog, also known as CCR4 carbon catabolite repression 4 like in S. cerevisiae, is encoded by the CCRN4L gene. This gene is involved in carbon catabolite repression and shares similarity with the CCR4 protein. It plays a crucial role in regulating carbon metabolism in yeast. Another common abbreviation for this protein is NOC.
Source	Rabbit
Specificity	The total CCRN4L levels can be accurately measured by using the CCRN4L Antibody, which specifically detects the endogenous levels of CCRN4L. By rearranging the original content, we can generate the following statement: The CCRN4L Antibody is capable of precisely identifying the endogenous amounts of total CCRN4L in biological samples.
Species Reactivity	Human;Mouse;Rat;Monkey
Predictive reaction species	Rabbit
Antigen	CCRN4L
Application	WB1:10001:3000，IF/ICC1:1001:500。，ELISA（）1:200001:40000。，。
Immunogen	A synthesized peptide derived from human CCRN4L.
MW	48 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum. Let me give you similar information by rearranging the content: The purification process of the antiserum utilized SulfoLink™ Coupling Resin in peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it in temperatures as low as -20 °C for up to one year. It is important to avoid exposing it to repeated freeze/thaw cycles as this can affect its efficacy.
Storage buffer	This product is composed of Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, 150mM of NaCl, 0.02% of sodium azide, and 50% of glycerol. To ensure maximum efficacy, it should be stored at a temperature of -20°C, and it remains stable for up to 12 months from the date of receipt.
Target
Background	Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity).
Tissue specificity	Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.
Celluar localization	Nucleus;
UniPort	Q9UK39