Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-CEP110 Polyclonal Antibody#abs138880

Please note that the price mentioned is for your reference only. For detailed pricing information, kindly get in touch with our seller, Vecent. It is important to note that the content generated here is not derived from ChapGPT dialogue generation model. Instead, it is based on language model...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs138880-100ug	1-2 Weeks	301.0
abs138880-50ug	1-2 Weeks	201.0

Overview
catalog	abs138880
Other names	CP110_HUMAN, also known as Centrosomal protein CP110, is a 110 kDa centrosomal protein that plays a crucial role in cell division. It is also referred to as CCP110 or Centriolar coiled coil protein 110kDa. Furthermore, it is recognized as Centrosomal protein of 110 kDa or FAN (Funding and Accounting Network). The protein, encoded by the KIAA0419 gene, is essential for the proper functioning of centrosomes, which are important cellular structures involved in organizing microtubules. CP110 is believed to regulate the length and stability of centrioles, contributing to accurate cell division and maintenance of genomic integrity. Its aberrant expression or dysfunction has been associated with various human diseases, including cancer. In conclusion, CP110 is a significant centrosomal protein that warrants further research to fully understand its various cellular functions and pathological implications.
Source	Rabbit
Specificity	The CEP110 Antibody is capable of identifying total CEP110 at the natural levels present in the body. To create a similar piece of content based on this information, one could say that the CEP110 Antibody is useful in detecting endogenous amounts of total CEP110 protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	CEP110
Application	The WB dilution range is 1:1000-3000, while the IHC dilution is 1:200. For ELISA using a peptide, the dilution range is 1:20000-1:40000. It is important to note that this generated content is not based on the original text information but rather a different way of presenting the information using a language model.
Immunogen	A synthesized peptide derived from human CEP110.
MW	113kDa
Properties
Concentration	1mg/ml
purification	Using the SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification purposes. This involved the isolation of specific peptides that bound to the resin, which facilitated the removal of impurities and other unwanted substances from the antiserum. Overall, this method helped to produce a highly purified antiserum that was suitable for further use.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	It is recommended to store Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, containing 150mM of NaCl, 0.02% of sodium azide, and 50% glycerol at a temperature of -20 °C. The product is stable for up to 12 months from the date of receipt.
Target
Background	Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).
Tissue specificity	Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Posttranslational modification	Phosphorylated by CDKs.Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate.
Celluar localization	Cytoskeleton;Cytosol;
UniPort	O43303