Rabbit Anti-Cathepsin E Polyclonal Antibody#abs131268
Please note that the price provided is only for reference purposes. For a more detailed price, kindly get in touch with our seller, Vecent. It is important to clarify that the content generated is not based on ChapGPT, rather, it is a unique arrangement of the original information using a...
Description
| Catalog-specification | Delivery time | USD price |
abs131268-100ug | 1-2 Weeks | 301.0 |
abs131268-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is only for reference purposes. For a more detailed price, kindly get in touch with our seller, Vecent. It is important to clarify that the content generated is not based on ChapGPT, rather, it is a unique arrangement of the original information using a different language model.
| Overview | |
catalog | abs131268 |
Description | It is believed that this protein possesses an important role in maintaining immune function. Its primary function may lie in the processing of antigenic peptides during MHC class II-mediated antigen presentation. It could also be involved in triggering activation-induced lymphocyte depletion in the thymus and causing neuronal degeneration and glial cell activation in the brain. |
| Other names | One possible rearrangement of the above content is: Cathepsin E, also known as CATE, CATE_HUMAN, Cathepsin E form II, CTSE, Erythrocyte membrane aspartic proteinase, or Slow moving proteinase, is an enzyme that belongs to the aspartic protease family. It is involved in the proteolytic processing of various proteins and functions in the lysosomal and endosomal compartments of the cell. Cathepsin E has been implicated in a wide range of physiological and pathological processes, including digestion, antigen processing, cell migration, and cancer progression. Its expression and activity are regulated by various factors, such as pH, inhibitors, and substrates. Cathepsin E is a potential target for therapeutic intervention in certain diseases, such as autoimmune disorders, infections, and cancers. Further research is needed to fully understand the molecular mechanisms of Cathepsin E and its role in health and disease. |
| Source | Rabbit |
| Specificity | The detection of endogenous levels of total Cathepsin E is achievable using the Cathepsin E Antibody. This antibody has the capability to specifically target and identify the overall amount of Cathepsin E present in a sample. It offers a reliable and efficient method for assessing the expression and activity of Cathepsin E in biological systems. By utilizing this antibody, researchers can gain valuable insights into the role of Cathepsin E in various physiological and pathological processes. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | Cathepsin E |
| Application | The dilution ranges for WB, IHC, IF/ICC, and ELISA (peptide) are as follows: - WB: 1:500 to 1:2000 - IHC: 1:50 to 1:200 - IF/ICC: 1:100 to 1:500 - ELISA (peptide): 1:20000 to 1:40000 To obtain optimal results, it is crucial to dilute the samples in the specified ranges. For western blotting (WB), dilutions should be performed at a ratio of 1:500 to 1:2000. Immunohistochemistry (IHC) requires dilutions ranging from 1:50 to 1:200. For immunofluorescence (IF) or immunocytochemistry (ICC), the recommended dilutions are 1:100 to 1:500. Lastly, when conducting an ELISA using peptides, the appropriate dilution range is 1:20000 to 1:40000. Following these dilution guidelines will ensure accurate and reliable results in your experiments. |
| Immunogen | A peptide that has been synthesized from human Cathepsin E is what we are referring to. To create a content that is highly similar, we need to rearrange the original text information. |
| MW | 43 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Utilizing SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. To ensure the retention of the original text information, the content has been rephrased while keeping the essence intact. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To ensure the integrity of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles. This storage condition will help maintain the efficacy and quality of the product over time. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. |
| Tissue specificity | Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes. |
| Posttranslational modification | Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57. |
| Celluar localization | Endosome;Extracellular region or secreted; |
| UniPort | P14091 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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