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Rabbit Anti-S100 A10 Polyclonal Antibody#abs131267

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Description

Catalog-specification	Delivery time	USD price
abs131267-100ug	1-2 Weeks	301.0
abs131267-50ug	1-2 Weeks	201.0

Overview
catalog	abs131267
Description	S100A10 plays a potential role in regulating protein phosphorylation by inducing the dimerization of ANXA2/p36. Based on in vitro experiments, the ANXA2 monomer appears to be the preferred substrate for tyrosine-specific kinase. Thus, this protein complex may be involved in modulating cell signaling pathways and cellular responses. Overall, this highlights the importance of understanding the complex interplay between different proteins and their functional roles in biological systems.
Other names	Protein S100-A10, also known as Annexin II ligand or calpactin I, is a calcium-binding protein that plays a role in various cellular processes. It is encoded by the ANXA2 gene and is composed of a light polypeptide chain, p11. This protein forms a tetramer called Annexin II tetramer (AIIt) along with Annexin II. Protein S100-A10 is involved in annexin II signaling and serves as a ligand for this receptor. It is also known as calpactin I light chain and can modulate the functions of annexin II. Additionally, this protein has been observed to be induced by nerve growth factor. The genetic code for protein S100-A10 is represented by several identifiers, including 42C, AA409961, and AL024248. Other aliases for this protein include CAL12, CAL1L, CLP11, GP11, MGC111133, and S10AA_HUMAN.
Source	Rabbit
Specificity	The S100 A10 Antibody is capable of detecting the total amount of S100 A10 present in the body. This detection is done with a focus on the naturally occurring levels of the protein. To expand on this concept further, it is important to note that the S100 A10 Antibody targets the endogenous sources of this substance, rather than artificially created sources. By using this approach to detection, researchers can establish an accurate baseline for the levels of S100 A10 in the body.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	S100A10
Application	The recommended dilutions for WB are 1:500-1:2000, while for IHC they are 1:50-1:200. For ELISA using peptide, the recommended dilutions range from 1:20000-1:40000. It's important to follow these guidelines to ensure accurate results in your experiments.
Immunogen	A synthesized peptide derived from human S100 A10.
MW	11 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Plasma Membrane;
UniPort	P60903