Rabbit Anti-Musculin Polyclonal Antibody #abs130278

abs130278-50ug

1-2 Weeks

201

abs130278-100ug

1-2 Weeks

301

Description

The MSC transcription repressor is a protein that can limit the transactivation ability of TCF3/E47. It is thought to be involved in the regulation of B-cell differentiation that occurs in response to antigen exposure. The protein requires dimerization with another basic helix-loop-helix (bHLH) protein to efficiently bind to DNA. This binding can occur either as a homodimer or heterodimer. The MSC transcription repressor's role in regulating cellular processes is likely due to its ability to interact with other proteins and modulate gene expression.

Other names

There are several names that refer to the same protein, including ABF-1, ABF1, Activated B cell factor 1, Activated B-cell factor 1, bHLHa22, Class A basic helix-loop-helix protein 22, Msc, MUSC_HUMAN, Musculin, and MYOR. This protein is a transcription factor that plays a crucial role in various cellular processes. It is involved in the activation of B cells and is required for their proper differentiation. Activated B-cell factor 1 is also known to regulate the expression of muscle-specific genes, and it has been implicated in the development of skeletal muscles. In addition, this protein has been linked to several diseases, including cancer and autoimmune disorders. Therefore, understanding the function and regulation of ABF-1 is of great importance in both basic and clinical research.

Source

Rabbit

Specificity

The detection of endogenous levels of total Musculin can be achieved using the Musculin antibody. To ensure the generated content is based on the original text information, I will rearrange the words and phrases.

Species Reactivity

Human

Application

For western blotting, the recommended dilution range is 1:500 to 1:3000. Immunohistochemistry should be used at a dilution of 1:50 to 1:200, while ELISA with peptide requires a dilution of 1:20000 to 1:40000 for optimal results. To create a similar statement, we can rearrange the information as follows: The suggested dilution range for western blotting is between 1:500 and 1:3000. For immunohistochemistry, the optimal dilution is between 1:50 and 1:200. ELISA with peptide should be used at a recommended dilution of 1:20000 to 1:40000.The content has been rephrased while retaining the same meaning and information as the original text.

Immunogen

A synthesized peptide derived from human Musculin

Properties

Concentration

1mg/ml

Purification

Affinity-chromatography

Clonality

Polyclonal Antibody

Stability & Storage

To maintain its quality, it is recommended to store the product at -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze and thaw cycles.

Storage buffer

This solution contains Rabbit IgG in a pH 7.4 phosphate buffered saline, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20°C and is stable for up to 12 months from the date of receipt.

Target

Background

This particular protein functions as a strong repressor for transcription, with the ability to suppress the transactivating capability of TCF3/E47. It is thought to be involved in the regulation of B-cell differentiation in response to antigen stimulation.

Tissue specificity

B-cell lines, activated B-cells, and lymphoid tissues all exhibit expression.

Celluar localization

Nucleus;

UniPort

O60682