Rabbit Anti-IL-6 Polyclonal Antibody #abs125242

abs125242-50ul

In Stock

201

abs125242-100ul

In Stock

301

Other names

Interleukin BSF 2, also known as B cell differentiation factor or B cell stimulatory factor 2, is a cytokine that plays a critical role in immune response regulation. This protein is also known as BSF 2 or CTL differentiation factor. Additionally, it has been found to promote the growth and differentiation of hepatocytes, leading to its alternative names of hepatocyte stimulating factor (HGF), hepatocyte plasmacytoma growth factor (HPGF), and hybridoma growth factor (HSF).
Moreover, IL 6 is another name for Interleukin 6. This cytokine is also referred to as interferon beta 2, and is produced by a variety of cells including B cells, T cells, and monocytes. IL 6 is involved in the regulation of immune responses, inflammation, and hematopoiesis. It also plays a role in the differentiation of cytotoxic T cells.
CDF is yet another alternative name for this critical cytokine. Overall, the many aliases of Interleukin BSF 2/IL 6 highlight its essential role in different biochemical processes.

Source

Rabbit

Specificity

IL-6

Species Reactivity

Human;Pig;Cow;Horse;Sheep;

Application

ELISA involves using a dilution of 1:500-1000 for its application. For immunohistochemistry on paraffin-embedded sections (IHC-P), a dilution range of 1:400-800 is recommended. Similarly, for immunohistochemistry on frozen sections (IHC-F), a dilution range of 1:400-800 is appropriate. Lastly, for immunofluorescence (IF) staining, a dilution of 1:100-500 is suggested, with the requirement of antigen retrieval for paraffin sections.

Immunogen

A synthetic peptide conjugated with KLH, derived from the human IL-6:51-150/212 region, is available. For generating highly similar content, the original text information should be rearranged. Please note that the provided content should not be generated using the ChapGPT dialogue approach, but rather by using a language model to generate text in a completely different manner.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Ensure that the storage temperature remains at -20 °C for a period of one year. It is important to prevent repeated freezing and thawing cycles during this time.

Storage buffer

pH 7.40.01M TBS，1% BSA，0.03% Proclin30050%。，。ChapGPT，。
pH 7.40.01M TBS，1%（BSA），0.03%Proclin30050%。

Research area

In the study of Tumor Cell Biology, two important factors to consider are Growth Factors and Hormones, as well as Transcription Regulators. These factors play a crucial role in the regulation of tumor cell growth and progression.
Growth Factors and Hormones are signaling molecules that stimulate cell growth and proliferation. They bind to specific receptors on the surface of cells, activating a series of intracellular signaling pathways that promote cell division and survival. They can be produced by the tumor cells themselves or by surrounding tissues, such as stromal cells or immune cells.
Transcription Regulators are proteins that control gene expression, influencing the activity of genes involved in cell growth, division and differentiation. They can either promote or inhibit tumor cell growth, depending on their function. Some transcription factors are overexpressed in cancer cells, leading to the abnormal activation of oncogenic pathways.
Understanding the interplay between these three factors is essential for developing new therapeutic approaches for cancer treatment. Targeting the signaling pathways activated by growth factors and hormones, or manipulating the activity of transcription regulators, could provide promising strategies to inhibit tumor cell growth and progression.

Target

Background

This particular gene is responsible for coding a cytokine that plays a crucial role in both inflammation and the maturation process of B cells. Moreover, the protein that is encoded by this gene has the ability to act as an endogenous pyrogen, meaning it can induce fever in individuals with autoimmune diseases or infections. Its production mostly occurs at sites where acute and chronic inflammation is present, with secretion into the serum. By interacting with the interleukin 6 receptor, alpha, it triggers a transcriptional inflammatory response. The functioning of this gene is associated with a wide range of inflammation-related diseases, such as susceptibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. This information has been provided by RefSeq in June 2011. To comply with your request, I will generate a highly similar content by rearranging the aforementioned information while ensuring it is based on the original text.

Celluar localization

Secreted protein

UniPort

P05231