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Rabbit Anti-CaMKII Polyclonal Antibody#abs133246

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Description

Catalog-specification	Delivery time	USD price
abs133246-100ug	1-2 Weeks	301.0
abs133246-50ug	1-2 Weeks	201.0

Overview
catalog	abs133246
Other names	The Calcium/calmodulin-dependent protein kinase type II subunit alpha and Calcium/calmodulin-dependent protein kinase type II subunit delta are two important proteins involved in the regulation of various cellular processes. CaM kinase II subunit alpha and CaM kinase II subunit delta, also known as CAM2, play a crucial role in signal transduction and are key players in several biological processes such as learning and memory. The CAMK2A and CAMK2B genes encode the CaMK-II subunit alpha and CaMK-II subunit delta, respectively, which are essential for the proper functioning of neurons in the brain. These proteins are involved in the regulation of neurotransmitter release and synaptic plasticity, which are critical for learning and memory formation. Additionally, CAMKA, CAMKB, and CAMKD are other genes that encode various isoforms of CaMKII. Each isoform has a unique function and plays a specific role in cellular signaling pathways. Interestingly, recent studies have suggested that dysregulation of CaMKII signaling may contribute to the development of several neurological disorders, including schizophrenia and Alzheimer's disease. Therefore, understanding the complex function of these proteins is crucial for developing novel therapeutic agents for these debilitating diseases.
Source	Rabbit
Specificity	The CaMKII Antibody is capable of detecting total CaMKII levels present naturally within the body.
Species Reactivity	Human;Mouse;Rat
Antigen	CaMKII
Application	The recommended dilutions for WB are 1:1000-3000, for IHC it is 1:200, and for ICC/IF and ELISA (peptide) it is 1:20000-1:40000. Please rearrange the content above to create a similar context while ensuring the information remains intact.
Immunogen	A synthesized peptide derived from human CaMKII.
MW	45,60 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, a peptide affinity chromatography method was employed to purify the antiserum. A highly similar content can be generated by rearranging the original content.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is essential to avoid subjecting the product to repeated cycles of freezing and thawing. By adhering to these storage guidelines, the product's longevity and effectiveness can be maximized.
Storage buffer	-20°CIgG，pH 7.4、150mM NaCl、0.02%50%，12，。，。
Target
Background	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Tissue specificity	Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
Posttranslational modification	Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
Celluar localization	Cytoskeleton;Cytosol;Endoplasmic reticulum;Nucleus;Plasma Membrane;
UniPort	Q13554