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Rabbit Anti-CALB2 Polyclonal Antibody#abs137310

Description

Catalog-specification	Delivery time	USD price
abs137310-100ug	1-2 Weeks	301.0
abs137310-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, please get in touch with our seller Vecent. It's important to emphasize that the content generated needs to be highly similar to the original text, simply rearranged and reworded. Please refrain from using ChapGPT or any similar text generation tool to ensure that the generated content is unique and not simply a copy of the original text.

Overview
catalog	abs137310
Other names	29 kDa calbindin, also known as CAB 29, CAB29, CAL 2, CAL2, CALB 2, CALB2, CALB2_HUMAN, Calbindin 2 29kDa, Calbindin 2, Calbindin D29K, Calbindin2, Calretinin, or CR, is a protein with a molecular weight of 29 kDa. It plays a crucial role in calcium signaling and buffering in various tissues and organs. Calbindin 2 is expressed in the brain, kidneys, pancreas, and other tissues. CAB 29, also known as CALB2, is an important calcium-binding protein that regulates intracellular calcium levels and maintains calcium homeostasis in cells. It is highly conserved across different species and has been extensively studied for its involvement in neuronal development and function. CALB2 is specifically expressed in neurons of the central and peripheral nervous systems and is often used as a marker for certain neuronal populations. The role of CALB2 in calcium signaling is particularly important for maintaining proper neuronal function. It acts as a buffer for intracellular calcium, preventing excessive calcium influx and maintaining optimal calcium concentrations. By doing so, CALB2 helps regulate various processes, including synaptic transmission, neuronal excitability, and neuronal survival. In addition to its role in calcium signaling, CALB2 is also implicated in other cellular processes. Studies have shown its involvement in neurotransmitter release, dendritic arborization, and axonal pathfinding during neuronal development. Abnormalities in CALB2 expression or function have been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, as well as with epilepsy and other neurological disorders. Overall, the versatile functions of CALB2 make it a crucial player in calcium homeostasis and neuronal function. Further research on this protein may provide valuable insights into the mechanisms underlying various neurological disorders and potentially lead to the development of new therapeutic strategies.
Source	Rabbit
Specificity	The CALB2 Antibody acknowledges total CALB2 at its natural levels within the body. To create a similar piece of content, the original sentence can be rephrased for clarity. The CALB2 Antibody specifically detects the overall amount of CALB2 that exists naturally in the body.
Species Reactivity	Human
Predictive reaction species	Xenopus;Dog;Horse
Antigen	CALB2
Application	ELISA(peptide) 1:20000-1:40000, WB 1:1000-3000, IF/ICC 1:100-1:500 are the recommended dilutions for different assays. The WB assay is recommended to be performed at a dilution range of 1:1000-3000, followed by the IF/ICC assay at a dilution range of 1:100-1:500. For ELISA using peptide antigens, a dilution range of 1:20000-1:40000 is suggested. These dilutions ensure optimal detection and accurate results for the respective assays.
Immunogen	A synthesized peptide derived from human CALB2.
MW	31 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography for its purification.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20°C for a duration of one year. It is important to avoid exposing the product to repeated cycles of freezing and thawing. This will ensure that the product remains effective and of high quality for its intended purpose.
Storage buffer	In order to store Rabbit IgG properly, it should be kept in phosphate buffered saline with a pH of 7.4, including 150mM NaCl and 0.02% sodium azide. Additionally, it should be stored in a -20 °C freezer and mixed with 50% glycerol. This mixture will remain stable for up to 12 months from the date it was received.
Target
Background	Calretinin is a calcium-binding protein which is abundant in auditory neurons.
Tissue specificity	Brain.
Celluar localization	Cytosol;Nucleus;
UniPort	P22676