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Rabbit Anti-Annexin II Polyclonal Antibody#abs131256

Description

Catalog-specification	Delivery time	USD price
abs131256-100ug	1-2 Weeks	301.0
abs131256-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is for your reference only. For the detailed price information, please get in touch with our seller, Vecent. To generate content that closely resembles the original text, you can rearrange the given information. Kindly note that the text should not be developed using the conversational approach of ChapGPT. Instead, try using a different language model to ensure that the generated content is distinct and unique.

Overview
catalog	abs131256
Description	This protein is a calcium-regulated membrane-binding protein that exhibits a significantly heightened affinity for calcium in the presence of anionic phospholipids. It has the capability to bind two calcium ions with a strong affinity. Additionally, there is a possibility that this protein plays a role in the response to heat stress.
Other names	Annexin A2, also known as Annexin II or ANXA2, is a protein that plays crucial roles in various cellular processes. It is encoded by the ANXA2 gene in humans and is also referred to as ANXA2_HUMAN. This protein is a heavy chain component of calpactin I, which is involved in calcium-dependent processes. In addition to its role in calcium signaling, Annexin A2 is also associated with other functions. Annexin A2 is a multifunctional protein that interacts with different molecules and participates in diverse cellular activities. For instance, it has been implicated in membrane trafficking, endocytosis, exocytosis, and cell adhesion. One of its well-known functions is its ability to bind to phospholipids in a calcium-dependent manner, enabling it to act as a molecular switch in various signal transduction pathways. Moreover, Annexin A2 has been implicated in tumor metastasis and invasion. It has been shown to interact with several proteins involved in cell migration, such as S100A10, tissue plasminogen activator (tPA), and plasminogen. This association with metastasis and invasion makes Annexin A2 an attractive target for cancer therapy. Furthermore, Annexin A2 is involved in the regulation of blood coagulation and fibrinolysis. It can bind to plasminogen and tissue plasminogen activator (tPA), promoting the conversion of plasminogen to plasmin, which degrades fibrin clots. Additionally, Annexin A2 has been identified as a potential diagnostic marker for several diseases, including cancer, cardiovascular diseases, and autoimmune disorders. In conclusion, Annexin A2 is a versatile protein with diverse functions in various biological processes. Its role in calcium signaling, membrane trafficking, cell adhesion, and its involvement in tumor metastasis and blood coagulation make it a significant molecule in cellular physiology and disease pathology.
Source	Rabbit
Specificity	The Annexin II Antibody is specifically designed to recognize and bind to the endogenous levels of total Annexin II present in a sample. This antibody is highly effective in detecting the presence of Annexin II, providing researchers with valuable information about its cellular distribution and expression levels. By utilizing the Annexin II Antibody, scientists can investigate the functional roles of Annexin II in various biological processes and gain insights into its involvement in disease development and progression.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	Annexin II
Application	IHC 1:50-1:200, WB 1:500-1:2000, ELISA (peptide) 1:20000-1:40000.
Immunogen	Human Annexin II can be used to synthesize a peptide with high similarity. This synthesized peptide is derived from Annexin II and retains the original text information. Please note that I will generate a highly similar content by rearranging the above information.
MW	38 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar content can be generated by rearranging the same information, ensuring that the content is based on the original text.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
Posttranslational modification	Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.ISGylated.
Celluar localization	Cytosol;Endosome;Extracellular region or secreted;Lysosome;Nucleus;Plasma Membrane;
UniPort	P07355

This product is for research use only, not for use in diagnostic prodecures or in human.

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