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Rabbit Anti-NGF Beta Polyclonal Antibody#abs131258

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Description

Catalog-specification	Delivery time	USD price
abs131258-100ug	1-2 Weeks	301.0
abs131258-50ug	1-2 Weeks	201.0

Overview
catalog	abs131258
Description	The development and maintenance of the sympathetic and sensory nervous systems rely heavily on nerve growth factor. This crucial factor acts as an extracellular ligand that activates the NTRK1 and NGFR receptors, which are responsible for initiating cellular signaling cascades. By doing so, these receptor tyrosine kinases play a vital role in regulating neuronal proliferation, differentiation, and survival.
Other names	Beta nerve growth factor, also known as Beta NGF, Beta-nerve growth factor or Beta-NGF, is a protein that plays a crucial role in the growth, maintenance, and survival of nerve cells. It is encoded by the NGFB gene and is expressed in various tissues, including the brain, heart, and skin. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type 5 (HSAN5). Beta nerve growth factor consists of 241 amino acids and is a member of the neurotrophin family of growth factors. It binds to a specific receptor called TrkA, which is found on the surface of nerve cells. This binding initiates a cascade of signaling events that ultimately lead to the growth and survival of the nerve cell. Studies have shown that Beta-NGF may be involved in the pathogenesis of various neurological disorders, including Alzheimer's disease, Huntington's disease, and Parkinson's disease. Additionally, it has been investigated as a potential treatment for nerve injuries and chronic pain. In conclusion, Beta nerve growth factor is a vital protein that plays a critical role in the growth, survival, and maintenance of nerve cells. It has significant therapeutic potential for a range of neurological disorders and conditions.
Source	Rabbit
Specificity	Total NGF beta can be detected by using NGF beta Antibody, which is capable of identifying endogenous levels in the body. This implies that the antibody is a reliable tool for detecting NGF beta in various biological samples. The ability to detect endogenous levels of total NGF beta makes this antibody ideal for a wide range of research applications. By using NGF beta Antibody, researchers can accurately identify the presence and level of NGF beta in biological samples, which can be crucial in understanding the role of this protein in various physiological and pathological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit
Antigen	NGF β
Application	The recommended dilution for the use of WB is between 1:500 and 1:2000, while for IHC it is between 1:50 and 1:200. For ELISA using peptide, the ideal dilution range is between 1:20000 and 1:40000. It is important to adhere to the recommended dilution ratios in order to achieve reliable and accurate results. These dilution ranges have been determined to ensure the optimum performance and sensitivity of the assays. Therefore, it is imperative to follow the protocols and guidelines provided by the manufacturers for the successful execution of these assays.
Immunogen	A synthesized peptide derived from human NGF beta.
MW	26 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was utilized for the purification of the antiserum, and the process involved the use of SulfoLink™ Coupling Resin. The resulting antiserum was significantly purified and ready for further use.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
Celluar localization	Endosome;Extracellular region or secreted;Golgi apparatus;
UniPort	P01138