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Rabbit Anti-ALKBH4 Polyclonal Antibody#abs132963

Description

Catalog-specification	Delivery time	USD price
abs132963-100ug	1-2 Weeks	301.0
abs132963-50ug	1-2 Weeks	201.0

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Overview
catalog	abs132963
Other names	FLJ20013, also known as 2010004B12Rik, ABH4, Abj4, or RGD1308608, is a protein involved in the repair of alkylated DNA. It belongs to the AlkB family of proteins and is a homolog of the AlkB protein found in E. coli. ABH4 is a probable alpha-ketoglutarate dependent dioxygenase and plays a crucial role in repairing DNA damage caused by alkylating agents. Its function is similar to that of the AlkB homolog 4 protein.
Source	Rabbit
Specificity	The detection of total ALKBH4 at endogenous levels can be achieved using the ALKBH4 antibody.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Zebrafish;Sheep;Dog;Bovine;Horse;
Antigen	ALKBH4
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	36 kDa
Properties
Concentration	1mg/ml
purification	A method used to purify the antiserum involved using SulfoLink™ Coupling Resin in peptide affinity chromatography. The resin facilitated the separation of specific peptides from the mixture and produced a pure antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	One year of storage is recommended at -20 °C. It is important to prevent repeated freeze/thaw cycles. Please make sure to follow these instructions to maintain the quality and integrity of the stored items.
Storage buffer	The solution containing Rabbit IgG is prepared in a buffer of phosphate, saline and a pH of 7.4. Additionally, it includes 150 millimoles of sodium chloride, 0.02% of sodium azide, and 50% glycerol. This ensures the stability and preservation of the antibody, making it ready-to-use for applications in various research areas.
Target
Background	Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.
Tissue specificity	Widely expressed, with highest expression in pancreas, ovary and spleen.
Celluar localization	Nucleus;
UniPort	Q9NXW9