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Rabbit Anti-RAN Polyclonal Antibody#abs131467

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Description

Catalog-specification	Delivery time	USD price
abs131467-50ug	1-2 Weeks	201.0
abs131467-100ug	1-2 Weeks	301.0

Overview
catalog	abs131467
Description	This GTP-binding protein is involved in nucleocytoplasmic transport, functioning as an essential component for both protein import into the nucleus and RNA export. It also plays a crucial role in chromatin condensation and regulation of the cell cycle. Its interaction with BIRC5/survivin is important for forming the mitotic spindle during cell division by acting as a physical scaffold, facilitating the delivery of the RAN effector molecule TPX2 to microtubules.
Other names	ARA24, also known as androgen receptor-associated protein 24, plays an important role in the regulation of androgen receptor activity. It is also involved in multiple cellular processes such as nucleocytoplasmic transport and mitotic spindle organization. ARA24 is a GTPase ran, a member of the RAS oncogene family, and has been identified as OK/SW-cl.81, LPS, Gsp1, RanGTPase, Ras-like protein TC4, TC4, and RASL2 8. Its interaction with the androgen receptor is essential for proper cellular function, making ARA24 a potential therapeutic target for various diseases. The structure and function of ARA24 continue to be an area of active research in the field of molecular biology.
Source	Rabbit
Specificity	The RAN Antibody is capable of identifying total RAN at the endogenous level.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;
Antigen	RAN
Application	The recommended dilutions for using this antibody in various applications are as follows: for Western Blotting, dilute at 1:500-1:2000; for Immunohistochemistry, dilute at 1:50-1:200; for Immunofluorescence, dilute at 1:100-1:500; and for ELISA(peptide), dilute at 1:20000-1:40000. It is important to dilute the antibody appropriately to ensure optimal results in your experiments. By following the recommended dilutions, you can achieve high specificity and sensitivity of the antibody for your target of interest in your chosen application. It is also recommended to perform optimization experiments to determine the best dilution for your specific experiment conditions. By doing so, you can improve the accuracy and reproducibility of your experimental results.
Immunogen	A synthesized peptide derived from human RAN.
MW	26 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification process of the antiserum was carried out through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport.
Tissue specificity	Expressed in a variety of tissues.
Celluar localization	Cytoskeleton;Cytosol;Endosome;Extracellular region or secreted;Nucleus;
UniPort	P62826