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Phospho-TALIN1 (Ser425) Rabbit Polyclonal Antibody#abs140344

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Description

Catalog-specification	Delivery time	USD price
abs140344-100ug	1-2 Weeks	301.0
abs140344-50ug	1-2 Weeks	201.0

Overview
catalog	abs140344
Other names	Talin-1, also known as Talin or TLN1, is a protein coded by the ILWEQ gene in humans. TLN1_HUMAN plays a crucial role in cell adhesion by linking integrins, which are transmembrane receptors, to the actin cytoskeleton inside cells. TLN is important in the formation and maintenance of tissues and organs. Alterations to TLN function have been linked to various diseases including cancer, cardiovascular disease, and autoimmune disorders. Understanding the functions of Talin and its interactions with other molecules is important for developing treatments for these conditions.
Source	Rabbit
Specificity	The TALIN1 (Phospho-Ser425) Antibody is specifically designed to recognize and detect the presence of endogenous levels of TALIN1 protein only when it is phosphorylated at Serine 425. This antibody is a valuable tool for researchers who are interested in studying the role of TALIN1 in cellular signaling pathways and physiological processes. By detecting the phosphorylated form of TALIN1, researchers can gain a deeper understanding of how this protein functions and contributes to various biological processes. Overall, the TALIN1 (Phospho-Ser425) Antibody is a reliable and effective research tool for investigating the complex network of molecular pathways that regulate the activity of TALIN1.
Species Reactivity	Human;Mouse
Predictive reaction species	Zebrafish;Chicken;Rabbit;Pig;Dog;Horse;Sheep
Antigen	TALIN1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	An artificially created peptide has been made using human TALIN1 (Phospho-Ser425) as its source material. To produce a closely related piece of text, the existing contents could be reorganized while maintaining the original text's information. However, it is essential to avoid relying solely on the ChapGPT-based approach and instead use a language model to generate a substantially different content and presentation style.
MW	270 kDa
Properties
Concentration	1mg/ml
purification	Sequential chromatography was used to purify the antibody from purified rabbit serum. This purification process involved affinity purification on both phospho- and non-phospho-peptide affinity columns.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to frequent freeze/thaw cycles, as this can impact its effectiveness and potency. Taking proper care of the product during storage will help ensure that it remains stable and effective over time.
Storage buffer	This Rabbit IgG is suspended in a solution of phosphate buffered saline, with a pH of 7.4, containing 150mM NaCl, and 0.02% sodium azide. It is also blended with 50% glycerol for storage purposes. It is recommended to keep this product stored at a temperature no higher than -20 °C, as it will remain stable for 12 months from the date of purchase.
Target
Background	Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Plasma Membrane;
UniPort	Q9Y490