Rabbit Anti-Abi1 Polyclonal Antibody#abs131240

abs131240-50ug

1-2 Weeks

201

abs131240-100ug

1-2 Weeks

301

Description

This protein may potentially hinder cell growth and transformation through its interaction with nonreceptor tyrosine kinases, ABL1 and/or ABL2. Additionally, it may be involved in the regulation of Erk pathway activation induced by epidermal growth factor. Furthermore, it has been shown to play a role in cytoskeletal reorganization and EGFR signaling. Alongside EPS8, it has been implicated in transmitting signals from Ras to Rac.

Other names

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Abl interactor 1, also known as Abelson interactor 1 or Abi-1, is a protein encoded by the ABI1_HUMAN gene. It is also referred to as Abl binding protein 4 or Abl interactor protein 1. Other names include Abl-binding protein 4, AblBP4, e3B1, Eps8 binding protein, Eps8 SH3 domain binding protein, Eps8 SH3 domain-binding protein, Eps8-binding protein, Hssh3bp1, Interactor protein AblBP4, NAP1, Nap1 binding protein, Nap1-binding protein, Nap1BP, Spectrin SH3 domain binding protein 1, and Spectrin SH3 domain-binding protein 1. The function and interactions of Abelson interactor 1 make it an important protein in various cellular processes.
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Source

Rabbit

Specificity

The total Abi 1 levels can be accurately identified by the Abi 1 Antibody, which specifically detects the endogenous presence of Abi 1. To maintain the relevance of the original text, the content should be rearranged with the same information.

Predictive reaction species

Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;

Application

ELISA(peptide)，WB 1:500-1:2000。，1:20000-1:40000ELISA。，。，，。，。

A synthesized peptide derived from human Abi 1.

Properties

1mg/ml

Purification

SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography process to purify the antiserum.

Clonality

Polyclonal Antibody

Please ensure that the product is stored at -20 °C for a duration of one year without undergoing repeated freeze/thaw cycles.

Storage buffer

The provided information is about Rabbit IgG, which is stored in phosphate buffered saline at pH 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The storage temperature is -20 °C, and it remains stable for 12 months from the date of receipt.

Target

Background

 May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.

Tissue specificity

Widely expressed, with highest expression in brain.

Celluar localization

Cytoskeleton;Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Nucleus;Plasma Membrane;

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