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Rabbit Anti-A1Up Polyclonal Antibody#abs140356

Description

Catalog-specification	Delivery time	USD price
abs140356-100ug	1-2 Weeks	301.0
abs140356-50ug	1-2 Weeks	201.0

Please note that the price provided is only for reference purposes. For detailed pricing information, kindly get in touch with our seller, Vecent. It is important to note that the content generated below may differ in structure and wording, as it will be based on a language model and not on the original text information provided.
Please be advised that the price indicated is only meant to serve as a guide. To obtain the accurate pricing information, kindly liaise with our Seller, Vecent. Please note that the content generated below might be completely different from the original text information as this is based on a language model.

Overview
catalog	abs140356
Other names	The 28S ribosomal protein S7 is also known by several other names including A1U, A1Up, AI663987, Ataxin 1 interacting ubiquitin like protein, and Ataxin 1 ubiquitin like interacting protein A1U. It is involved in various cellular processes and plays a crucial role in protein synthesis. Another name for this protein is Connexin43 interacting protein of 75 kDa or CIP75, which highlights its interaction with Connexin43. It is encoded by the C1orf6 gene and is also known as Ataxin-1 ubiquitin-like-interacting protein A1U. In addition to its role in protein synthesis, there is evidence to suggest that this protein is involved in other cellular processes such as the regulation of protein degradation. It is also known as MRP S7 and bMRP27a, which highlight its association with the mitochondrial ribosome. Furthermore, this protein is associated with several other names including RGD1308273, S7mt, UBIN, Ubiquilin 4, and Ubiquilin-4. These names reflect the different aspects of its function or areas of research interest.
Source	Rabbit
Specificity	The total levels of endogenous A1Up can be detected using the A1Up Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig
Antigen	A1Up
Application	WB 1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human A1Up.
MW	54kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography employing SulfoLink™ Coupling Resin was utilized to purify the antiserum. Let's craft a similar content by rearranging the provided information, while ensuring it remains based on the original text. The purification of the antiserum was carried out using SulfoLink™ Coupling Resin in peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure proper storage, maintain a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the product to multiple freeze and thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15280365). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).
Tissue specificity	Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver.
Posttranslational modification	Ubiquitinated; this does not lead to proteasomal degradation. May undergo both 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
Celluar localization	Cytosol;Endoplasmic reticulum;Nucleus;
UniPort	Q9NRR5