Rabbit Anti-5-HT-5A Polyclonal Antibody #abs130474

abs130474-50ug

1-2 Weeks

201

abs130474-100ug

1-2 Weeks

301

Description

The 5-HT(5A) receptor is just one of numerous receptors responsible for binding with serotonin, a crucial neurotransmitter, hormone, and mitogen. G proteins play a vital role in mediating the activity of this receptor. It falls under the G-protein coupled receptor 1 family. Let me generate a highly similar content by rearranging the information provided.

Other names

5-HT-5A receptor, also known as 5-HT5A or 5-hydroxytryptamine receptor 5A, is encoded by the HTR5A gene in humans. It plays a crucial role in serotonin signaling pathways. The serotonin receptor 5A is involved in various physiological processes such as mood regulation, cognition, and behavior. By rearranging the given information, we can emphasize the importance of this receptor in serotonin signaling. Please note that the following content is generated based on the original text information:
The HTR5A gene encodes the 5-HT-5A receptor, also referred to as the serotonin receptor 5A or 5-HT5A. This receptor is an essential component of serotonin signaling pathways in the human body. With its distinct molecular structure and function, the 5-HT-5A receptor influences various physiological processes, including mood regulation, cognition, and behavior. Understanding the role of 5-HT-5A in serotonin transmission is crucial for unraveling the complexities of these biological mechanisms. By studying this receptor, we can gain valuable insights into potential therapeutic interventions targeting serotonin-related disorders. The 5-HT5A receptor stands as a promising target for future research and drug development aimed at improving mental health and overall well-being.

Source

Rabbit

Specificity

The 5-HT-5A Antibody is capable of detecting the natural levels of 5-HT-5A protein within the body. This means that it can accurately identify and quantify the presence of 5-HT-5A in biological samples. By utilizing this antibody, researchers can gain a deeper understanding of the role that 5-HT-5A plays in various physiological processes, such as neurotransmission, mood regulation, and sleep-wake cycles. Overall, the 5-HT-5A Antibody is a powerful tool for investigating the function of this important protein in the body.

Species Reactivity

Human;Mouse;Rat

Application

The recommended dilutions for Western blotting range from 1:500 to 1:2000. For immunofluorescence and immunocytochemistry, the suggested dilutions are between 1:100 and 1:500. In ELISA assays using peptides, it is advisable to dilute the samples in the range of 1:20000 to 1:40000. Make sure to follow these guidelines to achieve accurate and reliable results.

Immunogen

A synthesized peptide derived from human 5-HT-5A.

Properties

Concentration

1mg/ml

Purification

By employing SulfoLink™ Coupling Resin, the purification of the antiserum was achieved through peptide affinity chromatography. Let me reiterate the significance of this process and its basis on the original text information.

Clonality

Polyclonal Antibody

Stability & Storage

Ensure that the content is stored for one year at a temperature of -20 °C. It is advised to avoid subjecting it to repeated freeze/thaw cycles.

Storage buffer

This product contains Rabbit IgG, which is suspended in phosphate buffered saline with a pH of 7.4. The solution also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. Be sure to store this product at a temperature of -20 °C for optimal performance and use within 12 months of receipt.

Target

Background

Serotonin, a biogenic hormone serving as a neurotransmitter, hormone, and mitogen, interacts with various receptors, including this one. This receptor is activated through G proteins.

Celluar localization

The endoplasmic reticulum, golgi apparatus, and plasma membrane are integral components of the cell. They play critical roles in cellular processes and work together to maintain cellular homeostasis.
The endoplasmic reticulum is a complex network of membrane-bound structures located throughout the cytoplasm. It is involved in the synthesis, folding, and transport of proteins. The endoplasmic reticulum also plays a crucial role in lipid metabolism and calcium ion storage.
The golgi apparatus, on the other hand, acts as a sorting and packaging organelle. It receives proteins and lipids from the endoplasmic reticulum and modifies them for transportation to their final destinations. The golgi apparatus consists of flattened stacks of membrane-bound compartments called cisternae.
The plasma membrane, also known as the cell membrane, surrounds the cell and separates its internal environment from the external one. It is composed of a phospholipid bilayer embedded with various proteins and acts as a barrier, controlling the movement of substances into and out of the cell. The plasma membrane also plays a crucial role in cellular communication and transport processes.
Overall, the endoplasmic reticulum, golgi apparatus, and plasma membrane work in coordination to ensure the proper functioning and survival of the cell. They are integral to various cellular processes and are essential components of all living organisms.

UniPort

P47898