Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Phospho-GRK1/2 (Tyr13) Rabbit Polyclonal Antibody#abs140205

Please note that the price mentioned above is only for your reference. To obtain the detailed price information, kindly get in touch with our seller Vecent. We request you to kindly refrain from using ChapGPT to generate content and instead use a language model to create entirely unique content....

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs140205-100ug	1-2 Weeks	301.0
abs140205-50ug	1-2 Weeks	201.0

Overview
catalog	abs140205
Other names	Beta-adrenergic receptor kinase 1 (ADRBK1), also known as ARBK1_HUMAN or BARK, is an important protein involved in the regulation of beta adrenergic receptors. Another name for this protein is Beta ARK 1 or Beta-ARK-1. It is encoded by the gene ADRBK1 and is also referred to as FLJ16718. Similarly, Beta-adrenergic receptor kinase 2 (ADRBK2), also known as ARBK2_HUMAN or BARK2, is another crucial protein involved in the regulation of beta adrenergic receptors. It is encoded by the gene ADRBK2 and is alternatively called Beta ARK 2 or Beta-ARK-2. Another protein involved in this regulatory pathway is G-protein coupled receptor kinase 2 (GRK2), encoded by the gene GRK2. It is also known as G-protein coupled receptor kinase 2 or ADRBK1. Furthermore, G-protein coupled receptor kinase 3 (GRK3) is yet another protein that plays a role in the regulation of G-protein coupled receptors. It is also referred to as GRK3 and is encoded by the GRK3 gene. It is worth mentioning that all these proteins possess the enzyme activity of the EC (Enzyme Commission) number 2.7.11.15, indicating their function as kinases in phosphorylating beta adrenergic receptors.
Source	Rabbit
Specificity	The antibody GRK1/2 (Phospho-Tyr13) specifically recognizes GRK1/2 proteins in their phosphorylated form at Tyr13. It is capable of detecting the endogenous levels of phosphorylated GRK1/2. To reiterate, the antibody solely targets Tyr13 phosphorylation of GRK1/2, providing a reliable method for its identification in biological samples.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Bovine;Dog
Antigen	GRK1/2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	GRK1/2 is a protein found in humans, and a synthesized peptide has been derived from it. This peptide specifically targets the phosphorylated tyrosine residue at position 13. It is important to note that the content generated should be highly similar to the original text and reflect the information provided. The conversation should not follow ChapGPT's method of generating content but should instead focus on producing a completely different way of expressing the given information through a language model.
MW	79KD
Properties
Concentration	1mg/ml
purification	Sequential chromatography on phospho- and non-phospho-peptide affinity columns was employed to purify the antibody from rabbit serum. The purified antibody was obtained through affinity purification, utilizing purified rabbit serum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Tissue specificity	Expressed in peripheral blood leukocytes.
Celluar localization	Cytosol;Plasma Membrane;
UniPort	P25098/P35626