BMP4 Polyclonal Antibody #abs115617

abs115617-50ul

In Stock

228

Other names

BMP2B;BMP2B1;MCOPS6;OFC11;ZYME

Source

Rabbit

Species Reactivity

Human,Mouse,Rat

Application

WB 1:500 - 1:2000
IF 1:50 - 1:200

Immunogen

A fusion protein that comprises the sequence for human BMP4 amino acids 30 to 300 (NP_570912.2) has been created using recombinant technology. To produce similar content, the amino acid sequence for human BMP4 between positions 30 to 300 has been utilized for the generation of a recombinant fusion protein.

Properties

Mouse heart,Rat heart

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
pH 7.3, PBS buffer containing 0.02% sodium azide and 50% glycerol is specified. To maintain the original text information, a rephrased content is presented.

Target

Background

This particular gene is responsible for coding a ligand that is secreted by the TGF-beta superfamily of proteins. Ligands from this family have the ability to bind to different TGF-beta receptors, which then results in the recruitment and activation of SMAD family transcription factors. These factors play a crucial role in regulating the expression of genes. The initial preproprotein encoded by this gene undergoes proteolytic processing to produce each subunit of the disulfide-linked homodimer. This protein is involved in the regulation of heart development and adipogenesis, the process of adipocyte formation. In human patients, mutations in this gene have been linked to conditions such as orofacial cleft and microphthalmia. Additionally, this encoded protein may also play a role in various cardiovascular diseases and human cancers. By analyzing its involvement in different pathological processes, it is evident that this gene possesses a significant impact on multiple aspects of human health and development.

Celluar localization

Secreted,extracellular matrix,extracellular space

UniPort

P12644