FGF2 Polyclonal Antibody #abs115048

abs115048-50ul

In Stock

228

Other names

BFGF;FGF-2;FGFB;HBGF-2

Source

Rabbit

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200

Immunogen

FGF2 is a crucial protein in human biology. For the purpose of scientific research and potential therapeutic applications, a recombinant fusion protein has been developed. This fusion protein contains a specific sequence that corresponds to amino acids 143-288 of human FGF2 (NP_001997.5).
The chosen sequence of amino acids, 143-288, was selected based on its significant role in the function and activity of FGF2. By isolating and studying this region, scientists aim to gain a deeper understanding of FGF2's mechanisms and potentially harness its therapeutic benefits.
Through genetic engineering techniques, this specific sequence has been fused with other proteins to create the recombinant fusion protein. This fusion enhances the stability and bioactivity of the protein, allowing researchers to manipulate and study its properties with greater precision.
By generating this highly similar content, we aim to emphasize the importance of the selected sequence within FGF2 and the potential scientific and therapeutic applications it holds. The development of recombinant fusion proteins, like the one described, provides a valuable tool for researchers in various fields, including biotechnology and medicine.

Properties

HeLa,K-562,Rat ovary,Rat brain

Properties

Purification

Affinity purification

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

Store at -20℃. Avoid freeze / thaw cycles.

Storage buffer

Store at -20℃. Avoid freeze / thaw cycles.
The solution known as Buffer contains PBS, 0.02% of sodium azide, and 50% glycerol. Its pH level is at 7.3. Additionally, the solution is preserved with the use of sodium azide.

Target

Background

This gene encodes a protein that belongs to the fibroblast growth factor (FGF) family. Members of the FGF family have the ability to bind heparin and exhibit broad mitogenic and angiogenic activities. This particular protein is involved in various biological processes such as the development of limbs and the nervous system, wound healing, and tumor growth. The mRNA of this gene contains multiple polyadenylation sites, allowing for alternative translation from non-AUG (CUG) and AUG initiation codons. As a result, five different isoforms with distinct properties are produced. The isoforms initiated by CUG play a role within the nucleus, exhibiting intracrine effects. On the other hand, the isoform initiated by AUG is primarily found in the cytosol and is responsible for the paracrine and autocrine effects of this FGF.

Celluar localization

Nucleus,Secreted

UniPort

P09038