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Rabbit Anti-ELN Polyclonal Antibody#abs136584

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Western blot analysis of extracts of various celllines, using ELN antibody. This product is for research use only, not for use...

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Description

Catalog-specification	Delivery time	USD price
abs136584-100ug	1-2 Weeks	301.0
abs136584-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.

Overview
catalog	abs136584
Description	The protein produced by this gene is crucial in the structure of elastic fibers, which are composed of two components. This encoded protein is abundant in hydrophobic amino acids like glycine and proline, resulting in the formation of flexible hydrophobic regions. These regions are connected through crosslinks involving lysine residues. Mutations and deletions in this specific gene have been linked to supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. It is worth noting that various transcript variants have been discovered for this gene, encoding different isoforms.
Other names	Tropoelastin, also known as elastin, is a protein encoded by the ELN gene in humans. It is a crucial component of elastic fibers found in various tissues, including skin, lungs, blood vessels, and ligaments. Mutations in the ELN gene have been associated with several genetic disorders, including Williams-Beuren syndrome (WBS) and supravalvular aortic stenosis (SVAS). Elastin is essential for the proper function of these tissues and plays a significant role in maintaining their elasticity and resilience. Understanding the structure and function of elastin is critical for the diagnosis and treatment of these disorders.
Source	Rabbit
Specificity	Total ELN levels can be detected by the ELN Antibody, which specifically targets endogenous ELN.
Species Reactivity	Human;Mouse;Rat
Antigen	ELN
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human ELN.
MW	69kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to perform peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	For one year, store at -20 °C and make sure to avoid repeated freeze/thaw cycles. It is crucial to follow these guidelines to maintain the quality of the product.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).
Tissue specificity	Expressed within the outer myometrial smooth muscle and throughout the arteriolar tree of uterus (at protein level). Also expressed in the large arteries, lung and skin.
Posttranslational modification	Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine.Hydroxylation on proline residues within the sequence motif, GXPG, is most likely 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
Celluar localization	Extracellular region or secreted;
UniPort	P15502