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Rabbit Anti-ANAPC4 Polyclonal Antibody#abs132949

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Description

Catalog-specification	Delivery time	USD price
abs132949-100ug	1-2 Weeks	301.0
abs132949-50ug	1-2 Weeks	201.0

Overview
catalog	abs132949
Description	The APC/C is a crucial component of cell cycle regulation and functions as an E3 ubiquitin ligase to promote the degradation of specific target proteins during mitosis and the G1 phase. Using ubiquitination, APC/C mediates the formation of polyubiquitin chains, with a preference for 'Lys-11' linkages. While also capable of forming 'Lys-48' and 'Lys-63' chains, this function is less prominent. Overall, the APC/C complex plays a critical role in maintaining proper cell division and controlling progression through the cell cycle.
Other names	Anapc4, also known as Anaphase Promoting Complex Subunit 4, APC 4, or Cyclosome subunit 4, is a crucial component of the APC Complex Protein CUT20. This protein plays an important role in the process of cell division by helping to regulate the separation of chromosomes during anaphase. Anapc4 works in conjunction with other proteins in the APC complex to ensure that the timing of cell division is coordinated properly. Additionally, mutations or defects in the APC4 gene have been linked to several types of cancer. This highlights the importance of understanding the function of Anapc4 in cellular processes. Researchers are currently conducting studies to uncover more about the mechanisms of Anapc4 and its potential as a target for cancer therapy.
Source	Rabbit
Specificity	The ANAPC4 antibody is capable of identifying the complete quantity of endogenous ANAPC4 protein. This means that it can effectively detect all forms and variations of ANAPC4 that are present within the sample. The generated content is based on the original text information, which emphasizes the antibody's ability to detect ANAPC4 at all levels, including those that are not readily visible or easily discernible.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Bovine;Horse;Pig;
Antigen	ANAPC4
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	92 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was employed to purify the antiserum utilizing SulfoLink™ Coupling Resin as the technique. To create a comparable content, the following information was rearranged while preserving the key details from the original text.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9UJX5