VWF Antibody #abs100459

abs100459-50ul

In Stock

228

Description

Purified Mouse Monoclonal Antibody (Mab)

Other names

Von Willebrand factor, also known as vWF or von Willebrand antigen 2, plays a significant role in blood clotting. This factor, referred to as VWF or F8VWF, is crucial for proper hemostasis. Its presence, indicated by von Willebrand antigen II, ensures stability and functionality of blood platelets. Understanding the importance of VWF and F8VWF in maintaining a balanced clotting system is essential for medical professionals.

Source

Mouse

Specificity

The antibody that we have was created by immunizing a mouse with .VWF recombinant protein. This means that our antibody has been specifically designed to target this protein and should be highly effective in its function. It is important to note that the generation of this antibody was based on the original text information, ensuring its accuracy and reliability. So if you are looking for a reliable and efficient way to target .VWF recombinant protein, our antibody is the way to go.

Species Reactivity

Human

Application

IHC-P~~1:25
FC~~1:100
WB~~1:1000

Properties

Clonality

Monoclonal Antibody

Clonality number

907CT12.1.9

Isotype

IgG1

Stability & Storage

To ensure optimal preservation, it is recommended to store the sample under refrigeration at temperatures ranging from 2 to 8°C for a maximum of two weeks. For extended storage, it is advisable to use small aliquots and freeze them at -20°C to prevent the formation of ice crystals resulting from freeze-thaw cycles.

Research area

Cancer;Cardiovascular;Signal Transduction

Target

Background

A critical role in maintaining hemostasis is played by promoting the adhesion of platelets to areas of vascular damage through the formation of a molecular bridge between the sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Additionally, it serves as a chaperone for coagulation factor VIII, transporting it to the injury site, ensuring its structural stability as a heterodimer, and safeguarding it against premature clearance from the bloodstream.

Celluar localization

Extracellular space and extracellular matrix contain secreted substances that are localized to storage granules.

UniPort

P04275

References

References

Bonthron D.,et al.Nucleic Acids Res. 14:7125-7128(1986).
Mancuso D.J.,et al.J. Biol. Chem. 264:19514-19527(1989).
Scherer S.E.,et al.Nature 440:346-351(2006).
Verweij C.L.,et al.EMBO J. 5:1839-1847(1986).
Verweij C.L.,et al.EMBO J. 5:3074-3074(1986).