BAP31 Antibody #abs100499

abs100499-50ul

In Stock

228

Description

Purified Mouse Monoclonal Antibody (Mab)

Other names

BCR-associated protein 31, also known as B-cell receptor-associated protein 31 or Bap31, is a multifunctional protein involved in various cellular processes. It is encoded by the DXS1357E gene and is also referred to as 6C6-AG tumor-associated antigen, protein CDM, p28, BCAP31, or BAP31.
BCR-associated protein 31 plays a critical role in protein trafficking and sorting within the cell. It is primarily localized in the endoplasmic reticulum (ER) and functions as a molecular chaperone for several membrane proteins, including immune receptors, signaling molecules, and viral glycoproteins.
The diverse functions of BCR-associated protein 31 make it essential for proper cellular function and immune responses. It is involved in mediating the transport of proteins from the ER to the Golgi apparatus, participating in the assembly of multiprotein complexes, and regulating the apoptosis pathway.
Moreover, BCR-associated protein 31 has been implicated in various pathological conditions, including cancer. Its association with the 6C6-AG tumor-associated antigen suggests a potential role in tumor development and progression.
In summary, BCR-associated protein 31, also known as Bap31 or BCAP31, is a versatile protein involved in protein trafficking, immune responses, and potentially tumor development. Its multifunctional nature and involvement in various cellular processes highlight its significance in normal and pathological conditions.

Source

Mouse

Specificity

The production of this BAP31 antibody involves the immunization of a mouse using a recombinant. It results in the generation of a highly specific and effective antibody for research use. The approach ensures that the generated content is based on the original text information, with the aim of providing accurate and credible information for use in scientific studies.

Species Reactivity

Human

Application

IHC-P~~1:25
WB~~1:2000

Properties

Clonality

Monoclonal Antibody

Clonality number

1502CT208.31.16

Isotype

IgG1,k

Stability & Storage

To ensure optimum storage conditions, it is recommended to maintain the product refrigerated between 2-8°C for a maximum period of 2 weeks. If you need to store it for a longer time, it is advisable to freeze it in small aliquots at -20°C to avoid any freeze-thaw cycles that may impair its quality. Remember that proper storage is critical to preserve the effectiveness of the product, so please follow these guidelines carefully.

Research area

Cell Biology;Signal Transduction

Target

Background

One of the most abundant proteins in the endoplasmic reticulum (ER), this protein functions as a chaperone. It plays a crucial role in various processes within the ER, such as exporting secreted proteins, recognizing misfolded proteins, and targeting them for degradation through ER-associated degradation (ERAD). Additionally, it acts as a cargo receptor for transmembrane protein export. Furthermore, there is a possibility that it is involved in CASP8-mediated apoptosis.

Celluar localization

The multi-pass membrane protein is found in the endoplasmic reticulum membrane and the endoplasmic reticulum-Golgi intermediate compartment membrane. It has the ability to shuttle between these two compartments and the cis-Golgi complex.

UniPort

P51572

References

References

Mosser J.,et al.Genomics 22:469-471(1994).
Li E.,et al.Eur. J. Biochem. 238:631-638(1996).
Adachi T.,et al.EMBO J. 15:1534-1541(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).