Recombinant Mouse IL-1 Receptor Type 2/IL-1 RII (C-6His) #abs04544

abs04544-10ug

1-2 Weeks

146

abs04544-50ug

1-2 Weeks

382

abs04544-500ug

1-2 Weeks

2353

abs04544-1mg

1-2 Weeks

3201

Description

Our Mammalian expression system produces Recombinant Mouse IL1R2 protein/IL-1 RII. The target gene, which encodes Phe14-Glu355, is expressed with a 6His tag at the C-terminus. This results in a highly purified and biologically active protein that is indistinguishable from the native protein. Our state-of-the-art techniques ensure that each batch of protein has consistent quality, with no variations in potency or activity. Experience the ultimate in quality and reliability with our Recombinant Mouse IL1R2 protein/IL-1 RII.

Other names

IL-1 receptor type 2, also known as IL-1R-2 or IL-1RT-2, is a protein that belongs to the CD121 antigen-like family member B. This protein plays a vital role in inhibiting the inflammatory activity of cytokines. CD121b also works as an inhibitor for the interleukin-1 receptor type I, which is responsible for initiating a pro-inflammatory response. IL-1R-beta is another name given to this receptor. It is the second receptor present in the interleukin-1 signaling pathway and is essential in controlling the immune response. The different names for this protein include the Interleukin-1 receptor type II and CD121b.

Source

Human Cells

Format

The sample was preserved by lyophilization after passing through a 0.2 μm filtered solution of PBS with pH level of 7.4. Would you like me to provide more information about the specifics of the sample preservation process?

Properties

aa_sequence

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Concentration

Ascertained through analysis of SDS-PAGE results, the level of similarity stands at over 95%. We can produce an analogous content by reorganizing the provided text so that it is consistent with the initial information.

Endotoxin_level

According to the results of the LAL test, the level of endotoxins in the sample was less than 0.1 ng/μg (equivalent to 1 IEU/μg).

Reconstitution

For optimal results, it is crucial to always centrifuge tubes before opening them. Avoid using vortex or pipetting methods for mixing. In order to maintain the desired concentration, it is advisable not to reconstitute the lyophilized protein to a level lower than 100 μg/ml. Use ddH2O to dissolve the lyophilized protein. To prevent degradation, it is recommended to aliquot the reconstituted solution and minimize freeze-thaw cycles. It is important to note that the content generated by ChapGPT must be significantly different from the original text, and should not follow the same pattern of rearranging the sentences.

Target

Background

Mouse Interleukin 1 receptor, type II (IL1R2) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. IL-1R2 structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain. It is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Mouse IL1RII shares 59% amino acid sequence homology with human IL1 RII in their extracellular domains. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2 has no signaling property and acts as a decoy for IL-1.

Accession

P27931