Recombinant Human Prostaglandin-H2 D-Isomerase/PTGDS (C-6His) #abs04373

abs04373-10ug

1-2 Weeks

161

abs04373-50ug

1-2 Weeks

482

abs04373-500ug

1-2 Weeks

2353

abs04373-1mg

1-2 Weeks

3201

Description

The Mammalian expression system is utilized to produce Recombinant Human Prostaglandin-D2 Synthase, which contains a 6His tag at the C-terminus. The target gene that codes for Ala23-Gln190 is expressed using this system, resulting in a highly pure and homogeneous product. Our production process ensures that the final product is highly similar to the original human Prostaglandin-D2 Synthase, delivering reliable and consistent results for research and therapeutic applications.

Other names

Lipocalin-Type Prostaglandin-D Synthase, Beta-Trace Protein, Prostaglandin-D2 Synthase, PGD2 Synthase, PTGDS, Cerebrin-28, Prostaglandin-H2 D-Isomerase, Glutathione-Independent PGD Synthase, PDS, PGDS2—these are the various names and acronyms associated with Prostaglandin-H2 D-Isomerase activity. This enzyme, also known as PGDS or PGD2 Synthase, plays a crucial role in the synthesis of the compound Prostaglandin D2. Additionally, Beta-Trace Protein, Cerebrin-28, and Lipocalin-Type Prostaglandin-D Synthase are alternative terms referring to PGDS. Glutathione-Independent PGD Synthase is another name for the enzyme responsible for Prostaglandin D2 synthesis. PTGDS is the official gene symbol for PGDS, whereas PDS and PGDS2 are other aliases used to represent this essential enzyme.

Source

Human Cells

Format

0.2μm，20mM TrisHCl、150mM NaCl、10%，pH7.5。，。

Properties

aa_sequence

LTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQVDHHHHHHAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLN。，，、。，、。，。，。，，。

Concentration

SDS-PAGE，95%。，。
SDS-PAGE，，95%。，，，95%。，，。，，。

Endotoxin_level

According to the LAL test, the concentration of the substance is found to be less than 0.1 ng/μg (1 IEU/μg). Let's rearrange the phrase and present the information in a slightly different manner. The LAL test determines that the substance concentration is lower than 0.1 ng/μg (equivalent to 1 IEU/μg).

Target

Background

Prostaglandin-H2 D-Isomerase (PTGDS) is a member of the Lipocalin family that belongs to the calycin superfamily. This protein is highly expressed in the brain and plays a crucial role in catalyzing the conversion of PGH2 to PGD2, which is a potent inhibitor of platelet aggregation and is also involved in smooth muscle contraction/relaxation. Besides this, PTGDS also has a significant role to play in a variety of functions in the central nervous system, including sedation, REM sleep and PGE2-induced allodynia, and may possess an anti-apoptotic function in oligodendrocytes.
Interestingly, PTGDS has been shown to have the ability to bind small, non-substrate, lipophilic molecules. This feature may allow it to function as a scavenger for harmful hydrophobic molecules and also act as a secretory retinoid and thyroid hormone transporter. PTGDS is also thought to participate in the development and maintenance of several barriers in the body, such as the blood-brain, blood-retina, blood-aqueous humor, blood-testis barriers, as well as the central nervous system and male reproductive system. Overall, PTGDS is a multifaceted protein with multifarious functions that play an essential role in various physiological processes.

Accession

P41222