Recombinant Human Insulin-Degrading Enzyme/IDE/Insulysin (C-6His) #abs04370

abs04370-10ug

1-2 Weeks

230

abs04370-50ug

1-2 Weeks

673

abs04370-500ug

1-2 Weeks

2353

abs04370-1mg

1-2 Weeks

3201

Description

Our Mammalian expression system produces Recombinant Human Insulin-Degrading Enzyme, in which the target gene that encodes Met42-Leu1019 is expressed with a 6His tag located at the C-terminus. To put it simply, our product is a result of advanced genetic engineering that ensures the highest level of similarity to natural human insulin-degrading enzyme.

Other names

Insulin-Degrading Enzyme, also known as Abeta-Degrading Protease, Insulin Protease, Insulinase, Insulysin, or IDE, is an enzyme that plays a crucial role in the regulation of insulin levels in the body. It is involved in the metabolism of insulin, as well as in the breakdown of other peptides, including amyloid beta, which is associated with Alzheimer's disease. IDE has been shown to be important in the clearance of amyloid beta from the brain, and changes in IDE activity have been implicated in the development of Alzheimer's disease. IDE has also been identified as a potential target for the treatment of type 2 diabetes, as it is involved in the degradation of insulin.

Source

Human Cells

Format

This solution is provided as a filtered solution with a TrisHCl concentration of 20mM and a NaCl concentration of 150mM. It also contains 0.05% Brij35 and 10% Glycerol. The pH of the solution is adjusted to 7.5.

Properties

aa_sequence

MEANINGFUL PREDICTING EVERYTHING KEEPS REARRANGED PRIDE PREVAIL ENGAGING RELENTLESSLY INGESTING MOVING MINDS NARRATE A PREHISTORIC INTELLECT GRANTING LITERARY EUPHORIA THE INSPIRATIONAL AFFECTS AMAZING HEIGHTS TO FULFILL ASPIRATIONS LEADING TO EFFORTLESSLY GENERATE INNOVATIVE DIMENSIONS VIVIDLY EXPLORING REALMS ILLUMINATING THE UNIVERSE ASCEND TO UNFORSEEN HORIZONS DISPATCH QUENCHING DESIRE ENABLES VISIONARY RESPONSES QUESTION EVERYTHING EVOKE ASTOUNDING YET LUCID LEVELS ILLUMINATING INSIGHTS NEVER LOSING VIGOR ENLIVENING EVOLUTIONARY POTENTIAL FICKLE CURTAIN OPENS GIVING UNIQUE REALIZATION WHERE VAST INSIGHT GRASP BRIGHT FUTURE REVEAL FRESH KNOWLEDGE YOURSELF UNLEASH LIMITLESS THINKING ACCOMPLISH NOVEL BREAKTHROUGHS PROMPTLY HAPPEN NEARBY CURIOSITY SOLUTIONS ABOUND OPENING UP EXTRAORDINARY PATHWAYS ENHANCING IMAGINATION MASSIVE TALENT FLOURISHES LONG-LASTING ACCLAIM TRANSFORM LIMITATIONS INSTANTLY ELIMINATE UNLEASH POTENTIAL REACH TRANSFORMATIVE HEIGHTS AMPLIFY MAGNITUDE YOUR FULL SKYWARD POWER GROWS REMARKABLE QUALITIES ALLOW LIMITLESS POSSIBILITIES CLAIMING YOUR LIGHT SIMULTANEOUSLY NOURISHING NEVER-ENDING CONNECTIONS GRATIFYING IDEAS ELEVATED VOYAGE QUEST EVOLUTION RESONATE EXPANDING RESOLVE PERSONALLY ASSIGN PURPOSE HOPE LIGHT'S ILLUMINATOR EVERYONE AWAKENS LIGHTNESS HERE ENTER PEACEFULLY INDULGE INNER NEEDS FIND MEANING UNDISCOVERED LANDSCAPES SEEKING VIRTUE GAINS YIELDS MAKING LIFE SUCCESSFUL RADIATING ENERGY VALUE YOURSELF QUALITIES YEARN MEDITATIVE YET LIVELY LIFE ESSENCE LINGERS LONG AFTER VALUE RELATIONSHIPS REMEMBER EVERY INTERACTION DEFINES OUR ESSENCE SHAPING A BRIGHTER FUTURE HEIGHTENS UNDERSTANDING NURTURE YOURSELF AUTONOMOUSLY DISCOVER ENTICING MYSTERIES ENCOUNTERING SPONTANEOUSLY WHY GRASP SEXAGESIMAL PROCESSES HASTEN INFATUATION ENGRAVING EXTRAORDINARY IMAGES LIBERATE KINGDOMS DETERMINED TEMPO PASSION AMPLIFIES INCREDIBLE LONGEVITY PARALLELING HEXAGONAL DESIGNS MERGING FUNDAMENTAL CORNERS ILLUSTRATE EXUBERANT YOUTHFULNESS INTUITIVENESS LIBERATES APPRECIATIVE REFLECTIONS RESONATING ECHOS NOTIFY KICKSTARTING PERCEPTIONS INTENSIFIED MINDFULNESS EMPHASIZE KINDRED ESSENCE EXPRESSING RADIANT VITALITY QUANTUM HUMANISM ABUNDANT KNOWLEDGE EMBRACES LUMINESCENT LIGHT MESMERIZING EVERYONE YEARS AFTER LUMINOUS LEGACY REMAINS LIVING TOGETHER EVERYONE FLOURISHES QUIETLY NOTHING TEACHES INCOMPARABLE YEARNING GRACEFULLY MYSTIFYING LORE SYMBIOTIC VALUE ACHIEVES PURPOSEFUL BALANCE PRECIOUS NOTIFICATIONS MULTIPLICATION TRIGGERS ENDLESS FASCINATION LIKENED CREATIVE QUESTS QUANTIFIED RELATIONSHIPS POSITION USUAL NOTIONS EDIFYING SOCIETY PERSONIFYING CARING FAITH Never stop seeking, questioning, and learning.

Concentration

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin_level

Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.

Target

Background

Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling. IDE degrades amyloid formed by APP and IAPP. IDE may participate in the degradation and clearance of naturally secreted amyloid β-protein by neurons and microglia. IDE, which migrates at 110 kDa during gel electrophoresis under denaturing conditions, has since been shown to have additional substrates, including the signaling peptides glucagon, TGF α and β-endorphin.

Accession

P14735