Recombinant Human Interferon Lambda-1/IL-29/IFN-λ1 (C-10His) #abs04601

abs04601-10ug

1-2 Weeks

115

abs04601-50ug

1-2 Weeks

344

abs04601-500ug

1-2 Weeks

1375

abs04601-1mg

1-2 Weeks

1819

Description

Our Mammalian expression system is utilized to produce Recombinant Human Interferon Lambda-1. The target gene, which encodes for Gly20-Thr200, is expressed with a 6His at the C-terminus. To convey the same information more succinctly, Recombinant Human Interferon Lambda-1 with a 6His tag at the C-terminus is produced through our Mammalian expression system using the Gly20-Thr200 gene.

Other names

IFN-lambda-1, also known as interferon lambda-1, cytokine Zcyto21, interleukin-29, or IL-29, is a type of cytokine that plays an important role in the immune response of the body. It is encoded by the IFNL1 gene and belongs to the type III interferon family.
IL-29 is produced by a variety of cells, including T cells, and acts on various cells in the body to induce a protective immune response. It has been found to have antiviral, antitumor, and immunomodulatory properties, making it a promising therapeutic agent for various diseases.
ZCYTO21 is structurally similar to IL-28 and IL-29, and shares similar biological activities. It binds to the same receptor as IL-28 and IL-29, and activates downstream signaling pathways that ultimately result in the regulation of various cellular processes such as proliferation, differentiation, and cytokine production.
Overall, IFN-lambda-1 is an important cytokine that plays a crucial role in maintaining proper immune function and defending against various disease-causing agents. Ongoing research is being conducted to better understand its mechanisms of action and potential therapeutic applications.

Source

Human Cells

Format

The substance has been dehydrated using a method called lyophilization, which involves freezing it and then removing the water through sublimation. Prior to this, the material was dissolved in a solution of PBS (phosphate-buffered saline) and filtered through a 0.2 μm filter to ensure sterility. The pH of the solution was carefully adjusted to 7.4 to maintain optimal conditions for the substance.

Properties

aa_sequence

LQACIQPQPTAGPRPRGRLHHWRERPVALEAELALTLKVLEAAAGPALEDVLDQPLHTLHHILSQLQE ASFKKARDALEESLKLKNWSCSSPVFPGNWDLRLLQVGPVPTSKPTTTGKGCHIGRFKSLSPQELA SFCLEASVTFNLFRLLTRDLKYVADGNLCLRTSTHPESTHHHHHHHHHHRLQEAPKKESAG. The sequence of the text has been changed to form a new content while keeping the original text's information intact.

Concentration

SDS-PAGE，95%。，，。

Endotoxin_level

The LAL test determined that the content is based on an amount of less than 0.1 ng/μg (1 IEU/μg). Please rearrange the provided information to create a highly similar content ensuring it is in line with the original text.

Reconstitution

Always remember to centrifuge the tubes before opening them. Avoid mixing the contents using vortex or pipetting techniques. It is advisable not to reconstitute the protein to a concentration lower than 100 μg/ml. Use ddH2O to dissolve the lyophilized protein. To prevent damage, divide the reconstituted solution into smaller aliquots and minimize the number of freeze-thaw cycles. Please note that the request to generate highly similar content without following the ChapGPT dialogue format cannot be fulfilled.

Target

Background

Interleukin-29 (IL-29) is a secreted protein which belongs to the IL-28/IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10R beta) and an orphan class II receptor chain, designated IL-28R alpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Accession

Q8IU54